The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and
studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular …

The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant
transformation, prevention of apoptosis, drug resistance and metastasis. The expression of this …

Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a complex array
of critical cellular processes. It was initially identified in rat skeletal muscle as a serine/…

Early tumorigenesis is associated with the engagement of the DNA-damage checkpoint
response (DDR) 1 , 2 . Cell proliferation and transformation induced by oncogene activation are …

Twist1 and Twist2 are major regulators of embryogenesis. Twist1 has been shown to favor
the metastatic dissemination of cancer cells through its ability to induce an epithelial-…

p53 has a key role in the negative regulation of cell proliferation, in the maintenance of
genomic stability, and in the suppression of transformation and tumorigenesis. To identify novel …

To investigate the molecular events that may underpin dysfunctional repair processes that
characterize idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP), we analyzed …

Oncogene activation increases susceptibility to apoptosis. Thus, tumorigenesis must depend,
in part, on compensating mutations that protect from programmed cell death. A functional …

Atypical lipomatous tumours (ALTs) represent a distinctive subset of mesenchymal neoplasms
featuring mature adipocytic differentiation. Most ALTs are characterized cytogenetically by …

Background Among sarcomas, which are rare cancers, many types are exceedingly rare;
however, a definition of ultra‐rare cancers has not been established. The problem of ultra‐rare …