Lipids play important modulatory and structural roles for membrane proteins. Molecular
dynamics simulations are frequently used to provide insights into the nature of these protein–…

Hyaluronan is an acidic heteropolysaccharide comprising alternating N-acetylglucosamine
and glucuronic acid sugars that is ubiquitously expressed in the vertebrate extracellular …

10.7554/eLife.15598.001 The essential process of protein secretion is achieved by the
ubiquitous Sec machinery. In prokaryotes, the drive for translocation comes from ATP hydrolysis …

Membranes in cells have defined distributions of lipids in each leaflet, controlled by lipid
scramblases and flip/floppases. However, for some intracellular membranes such as the …

Lipid droplets (LDs) are universal lipid storage organelles with a core of neutral lipids, such
as triacylglycerols, surrounded by a phospholipid monolayer. This unique architecture is …

Integral membrane proteins are localized and/or regulated by lipids present in the surrounding
bilayer. While bacteria have relatively simple membranes, there is ample evidence that …

Protein–lipid interactions are a key element of the function of many integral membrane
proteins. These potential interactions should be considered alongside the complexity and …

Maintenance of bacterial cell shape and resistance to osmotic stress by the peptidoglycan (PG)
renders PG biosynthetic enzymes and precursors attractive targets for combating …

Potassium homeostasis is vital for all organisms, but is challenging in single-celled organisms
like bacteria and yeast and immobile organisms like plants that constantly need to adapt …

Lipopolysaccharide (LPS) transport to the outer membrane (OM) is a crucial step in the
biogenesis of microbial surface defenses. Although many features of the translocation …