Ovarian cancer is the fourth most common cancer in women in the Western world. In a pilot
scale study, we highlight changes in the total serum glycome of patients with advanced …

Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse
secretome, which provides complex functionality for senescent cells within the tissue …

Forward genetic screens in Drosophila melanogaster for modifiers of position-effect variegation
have revealed the basis of much of our understanding of heterochromatin. We took an …

The retromer complex is required for the efficient endosome-to-Golgi retrieval of the CIMPR,
sortilin, SORL1, wntless and other physiologically important membrane proteins. Retromer …

Aberrant glycosylation on glycoproteins that are either presented on the surface or secreted
by cancer cells is a potential source of disease biomarkers and provides insights into …

Background: Liver biopsy is currently the gold standard for assessing liver fibrosis, and no
reliable noninvasive diagnostic approach is available. Therefore a suitable serologic …

SNPs in the first intron of FTO (fat mass and obesity associated) are strongly associated with
human obesity. While it is not yet formally established that this effect is mediated through the …

Critical cell surface immunoreceptors downregulated during HIV infection have previously
been identified using non-systematic, candidate approaches. To gain a comprehensive, …

Although adaptor protein complex 1 (AP-1) and Golgi-localized, γ ear-containing, ADP-ribosylation
factor-binding proteins (GGAs) are both adaptors for clathrin-mediated intracellular …

Despite recent advances in mass spectrometry, proteomic characterization of transport vesicles
remains challenging. Here, we describe a multivariate proteomics approach to analyzing …