User profiles for Robin Elaine Duncan

Robin Duncan

Assistant Professor, Kinesiology, University of Waterloo
Verified email at uwaterloo.ca
Cited by 5246

Regulation of lipolysis in adipocytes

RE Duncan, M Ahmadian, K Jaworski… - Annu. Rev …, 2007 - annualreviews.org
Lipolysis of white adipose tissue triacylglycerol stores results in the liberation of glycerol and
nonesterified fatty acids that are released into the vasculature for use by other organs as …

[PDF][PDF] Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype

…, VT Samuel, GI Shulman, Y Wang, RE Duncan… - Cell metabolism, 2011 - cell.com
While fatty acids (FAs) released by white adipose tissue (WAT) provide energy for other
organs, lipolysis is also critical in brown adipose tissue (BAT), generating FAs for oxidation and …

Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue

…, E Sarkadi-Nagy, RE Duncan… - American Journal …, 2007 - journals.physiology.org
Triacylglycerol (TAG) stored in adipose tissue can be rapidly mobilized by the hydrolytic action
of lipases, with the release of fatty acids (FA) that are used by other tissues during times of …

AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency

…, M Ahmadian, RE Duncan, E Sarkadi-Nagy… - Nature medicine, 2009 - nature.com
A main function of white adipose tissue is to release fatty acids from stored triacylglycerol for
other tissues to use as an energy source. Whereas endocrine regulation of lipolysis has …

Triacylglycerol metabolism in adipose tissue

…, RE Duncan, K Jaworski, E Sarkadi-Nagy… - Future …, 2007 - Taylor & Francis
Triacylglycerol (TAG) in adipose tissue serves as the major energy storage form in higher
eukaryotes. Obesity, resulting from excess white adipose tissue, has increased dramatically in …

Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity

M Ahmadian, RE Duncan, KA Varady, D Frasson… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE To investigate the role of desnutrin in adipose tissue triacylglycerol (TAG) and
fatty acid metabolism. RESEARCH DESIGN AND METHODS We generated transgenic mice …

Regulation of HMG-CoA reductase in MCF-7 cells by genistein, EPA, and DHA, alone and in combination with mevastatin

RE Duncan, A El-Sohemy, MC Archer - Cancer letters, 2005 - Elsevier
We investigated the regulation of HMG-CoA reductase in MCF-7 human breast cancer cells
by genistein, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). All three …

[HTML][HTML] Regulatory effects of cannabidiol on mitochondrial functions: a review

JZ Chan, RE Duncan - Cells, 2021 - mdpi.com
Cannabidiol (CBD) is part of a group of phytocannabinoids derived from Cannabis sativa.
Initial work on CBD presumed the compound was inactive, but it was later found to exhibit …

Geraniol and β-ionone inhibit proliferation, cell cycle progression, and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG …

RE Duncan, D Lau, A El-Sohemy, MC Archer - Biochemical pharmacology, 2004 - Elsevier
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase catalyzes the formation of
mevalonate, a precursor of cholesterol that is also required for cell proliferation. Mevalonate …

[HTML][HTML] Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA)

RE Duncan, E Sarkadi-Nagy, K Jaworski… - Journal of biological …, 2008 - ASBMB
Phospholipases A 2 (PLA 2 s) catalyze hydrolysis of fatty acids from the sn-2 position of
phospholipids. Here we report the identification and characterization of a membrane-associated …