Background The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a
member of the CRISPR (Clustered regularly interspaced short palindromic repeats) …

Global tuberculosis incidence has declined marginally over the past decade, and tuberculosis
remains out of control in several parts of the world including Africa and Asia. Although …

Rationale: In a high–tuberculosis (TB) incidence area of Cape Town, South Africa, there is a
very high rate of unexplained recurrent TB. The incidence of new bacteriologically …

M. tuberculosis is evolving antibiotic resistance, threatening attempts at tuberculosis epidemic
control. Mechanisms of resistance, including genetic changes favored by selection in …

Background The PE and PPE multigene families of Mycobacterium tuberculosis comprise
about 10% of the coding potential of the genome. The function of the proteins encoded by …

… Correspondence and requests for reprints should be addressed to Robin M. Warren, MD,
MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, …

The prevalence of infection among household contacts of people with tuberculosis is high.
This information frequently guides active case finding. We analysed DNA fingerprints of …

Anti-tuberculosis drugs are a two-edged sword. While they destroy pathogenic M. tuberculosis
they also select for drug resistant bacteria against which those drugs are then ineffective. …

A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis
is required to accelerate the development of rapid drug susceptibility testing methods …

Seven outbreaks involving increasing numbers of banded mongoose troops and high death
rates have been documented. We identified a Mycobacterium tuberculosis complex …