While depression and chronic pain are frequently comorbid, underlying neuronal circuits
and their psychopathological relevance remain poorly defined. Here we show in mice that …

Mutations in the charged multivesicular body protein 2B (CHMP2B) are associated with
frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and with a mixed ALS–FTD …

CHMP2B is a protein that coordinates membrane scission events as a core component of the
ESCRT machinery. Mutations in CHMP2B are an uncommon cause of amyotrophic lateral …

Amyotrophic lateral sclerosis and frontotemporal dementia are two neurodegenerative diseases
with currently no cure. These two diseases share a clinical continuum with overlapping …

While depression and chronic pain are frequently comorbid, underlying neuronal circuits, and
their relevance for the understanding of psychopathology, remain poorly defined. Here we …

… ), Robin Waegaert and Thibaut Burg (and your fun), Christine Marques (and your help),
Alexia Menuet (and your positive mind). I thank my former lab fellows Lavinia Palamiuc and …

Mutation in the CHMP2B gene has been implicated in frontotemporal dementia. The authors
screened CHMP2B in patients with ALS and several cohorts of control samples. They …

Background: In amyotrophic lateral sclerosis (ALS), the origin of fasciculations is disputed. We
hypothesized that the discharge pattern of fasciculation potentials (FPs) would be different …

Frontotemporal dementia ( FTD ), the second most common form of dementia in people
under 65 years of age, is characterized by progressive atrophy of the frontal and/or temporal …

Synaptic loss is a pathological feature of all neurodegenerative diseases including
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is a disease of the …