User profiles for Robin Yeo
 | Robin W. YeoBiological Data Scientist, Epic Bio Verified email at stanford.edu Cited by 1036 |
Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging
…, A McKay, EA Pollina, BW Dulken, X Zhao, RW Yeo… - Science, 2018 - science.org
In the adult brain, the neural stem cell (NSC) pool comprises quiescent and activated populations
with distinct roles. Transcriptomic analysis revealed that quiescent and activated NSCs …
with distinct roles. Transcriptomic analysis revealed that quiescent and activated NSCs …
[PDF][PDF] Aging and rejuvenation of neural stem cells and their niches
Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …
declining cognitive function and enhanced risk of brain diseases, including cancer and …
[PDF][PDF] Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal
Low energy states delay aging in multiple species, yet mechanisms coordinating energetics
and longevity across tissues remain poorly defined. The conserved energy sensor AMP-…
and longevity across tissues remain poorly defined. The conserved energy sensor AMP-…
Chromatin accessibility dynamics reveal novel functional enhancers in C. elegans
AC Daugherty, RW Yeo, JD Buenrostro… - Genome …, 2017 - genome.cshlp.org
Chromatin accessibility, a crucial component of genome regulation, has primarily been
studied in homogeneous and simple systems, such as isolated cell populations or early-…
studied in homogeneous and simple systems, such as isolated cell populations or early-…
Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium
Background Memory performance in older persons can reflect genetic influences on cognitive
function and dementing processes. We aimed to identify genetic contributions to verbal …
function and dementing processes. We aimed to identify genetic contributions to verbal …
[HTML][HTML] Males induce premature demise of the opposite sex by multifaceted strategies
Interactions between the sexes negatively impact health in many species. In Caenorhabditis,
males shorten the lifespan of the opposite sex—hermaphrodites or females. Here we use …
males shorten the lifespan of the opposite sex—hermaphrodites or females. Here we use …
Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes
10.7554/eLife.46418.001 Sexual interactions have a potent influence on health in several
species, including mammals. Previous work in C. elegans identified strategies used by males …
species, including mammals. Previous work in C. elegans identified strategies used by males …
In vitro and in vivo CRISPR-Cas9 screens reveal drivers of aging in neural stem cells of the brain
Aging impairs the ability of neural stem cells to transition from quiescence to activation (proliferation)
in the adult mammalian brain. Neural stem cell (NSC) functional decline results in …
in the adult mammalian brain. Neural stem cell (NSC) functional decline results in …
Improving few-shot learning-based protein engineering with evolutionary sampling
Designing novel functional proteins remains a slow and expensive process due to a variety
of protein engineering challenges; in particular, the number of protein variants that can be …
of protein engineering challenges; in particular, the number of protein variants that can be …
[HTML][HTML] Chromatin accessibility dynamics of neurogenic niche cells reveal defects in neural stem cell adhesion and migration during aging
The regenerative potential of brain stem cell niches deteriorates during aging. Yet the
mechanisms underlying this decline are largely unknown. Here we characterize genome-wide …
mechanisms underlying this decline are largely unknown. Here we characterize genome-wide …