Precision medicine integrating whole-genome sequencing, comprehensive metabolomics, and advanced imaging

…, IV Cohen, TJ Jönsson, R Heister… - Proceedings of the …, 2020 - National Acad Sciences
Genome sequencing has established clinical utility for rare disease diagnosis. While increasing
numbers of individuals have undergone elective genome sequencing, a comprehensive …

[HTML][HTML] An unsupervised learning approach to identify novel signatures of health and disease from multimodal data

…, ET Cirulli, L Huang, LA Napier, RR Heister… - Genome medicine, 2020 - Springer
Background Modern medicine is rapidly moving towards a data-driven paradigm based on
comprehensive multimodal health assessments. Integrated analysis of data from different …

Ventilation patterns in patients with severe traumatic brain injury following paramedic rapid sequence intubation

DP Davis, R Heister, JC Poste, DB Hoyt, M Ochs… - Neurocritical Care, 2005 - Springer
Introduction: Inadvertent hyperventilation has been documented during aeromedical transports
but has not been studied following paramedic rapid sequence intubation (RSI). The San …

Impact of helical computed tomography on the rate of negative appendicitis

TF Vadeboncoeur, RR Heister, CA Behling… - The American journal of …, 2006 - Elsevier
OBJECTIVE: To assess the impact of helical computed tomography (HCT) on the rate of
negative appendicitis (NA). METHODS: A before-and-after comparison study comparing data …

[HTML][HTML] A systematic review and recommendations around frameworks for evaluating scientific validity in nutritional Genomics

…, V Garneau, D Zavala-Mora, RR Heister… - Frontiers in …, 2021 - frontiersin.org
Background: There is a significant lack of consistency used to determine the scientific validity
of nutrigenetic research. The aims of this study were to examine existing frameworks used …

Precision medicine advancements using whole genome sequencing, noninvasive whole body imaging, and functional diagnostics

…, M Hicks, ET Cirulli, IV Cohen, TJ Jönsson, R Heister… - BioRxiv, 2018 - biorxiv.org
We report the results of a three-year precision medicine study that enrolled 1190 presumed
healthy participants at a single research clinic. To enable a better assessment of disease risk …

Unsupervised integration of multimodal dataset identifies novel signatures of health and disease

…, ET Cirulli, L Huang, LA Napier, RR Heister… - bioRxiv, 2018 - biorxiv.org
Modern medicine is rapidly moving towards a data-driven paradigm based on comprehensive
multimodal health assessments. We collected 1,385 data features from diverse modalities, …

Addition of Genetics to Quantitative MRI Facilitates Earlier Prediction of Dementia: A Non-invasive Alternative to Amyloid Measures

…, D Tkach, I Shomorony, N Shah, P Garst, R Heister… - bioRxiv, 2019 - biorxiv.org
Background Alzheimer’s disease is a major health problem, affecting ~4⋅5% of people aged
60 and older in 2016 with over 43 million affected globally 1 . The traditional approach for …

Precision medicine advanced by full body imaging biomarkers, whole genomic sequencing and blood-based measures

…, YC Hou, CL Swisher, HC Yu, R Heister… - archive.ismrm.org
We present the findings from 1190 presumed healthy patients evaluated at a precision
medicine clinic. We performed deep quantitative multimodal phenotyping and genotyping …

Stingray envenomation: a retrospective review of clinical presentation and treatment in 119 cases

RF Clark, RH Girard, D Rao, BT Ly, DP Davis - The Journal of emergency …, 2007 - Elsevier
Stingray stings are common along coastal regions of this country and the world. The tail of
the stingray contains a barbed stinger attached to a venom gland and contained within an …