User profiles for Rochelle L. Tiedemann
 | Rochelle TiedemannBioinformatics Research Scientist, Van Andel Institute Verified email at vai.org Cited by 768 |
[HTML][HTML] Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells
Background The TET family of dioxygenases catalyze conversion of 5-methylcytosine (5mC)
to 5-hydroxymethylcytosine (5hmC), but their involvement in establishing normal 5mC …
to 5-hydroxymethylcytosine (5hmC), but their involvement in establishing normal 5mC …
[PDF][PDF] Examining the roles of H3K4 methylation states with systematically characterized antibodies
…, D Maryanski, MJ Meiners, RL Tiedemann… - Molecular cell, 2018 - cell.com
Histone post-translational modifications (PTMs) are important genomic regulators often
studied by chromatin immunoprecipitation (ChIP), whereby their locations and relative …
studied by chromatin immunoprecipitation (ChIP), whereby their locations and relative …
[PDF][PDF] Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome-wide in human tumor cells
DNA methylation, mediated by the combined action of three DNA methyltransferases (DNMT1,
DNMT3A, and DNMT3B), is essential for mammalian development and is a major …
DNMT3A, and DNMT3B), is essential for mammalian development and is a major …
[PDF][PDF] Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and oncogenic properties
…, D Fan, Y Nie, S Yegnasubramanian, RL Tiedemann… - Cancer Cell, 2019 - cell.com
UHRF1 facilitates the establishment and maintenance of DNA methylation patterns in
mammalian cells. The establishment domains are defined, including E3 ligase function, but the …
mammalian cells. The establishment domains are defined, including E3 ligase function, but the …
[HTML][HTML] Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis
RA Hlady, RL Tiedemann, W Puszyk, I Zendejas… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths
worldwide. Deregulated DNA methylation landscapes are ubiquitous in human cancers. …
worldwide. Deregulated DNA methylation landscapes are ubiquitous in human cancers. …
[HTML][HTML] Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma
Clear cell renal cell carcinomas (ccRCCs) harbor frequent mutations in epigenetic modifiers
including SETD2, the H3K36me3 writer. We profiled DNA methylation (5mC) across the …
including SETD2, the H3K36me3 writer. We profiled DNA methylation (5mC) across the …
[PDF][PDF] Epigenomic reprogramming toward mesenchymal-epithelial transition in ovarian-cancer-associated mesenchymal stem cells drives metastasis
A role for cancer cell epithelial-to-mesenchymal transition (EMT) in cancer is well established.
Here, we show that, in addition to cancer cell EMT, ovarian cancer cell metastasis relies …
Here, we show that, in addition to cancer cell EMT, ovarian cancer cell metastasis relies …
Oocyte age and preconceptual alcohol use are highly correlated with epigenetic imprinting of a noncoding RNA (nc886)
…, Z Madaj, L Brink, RL Tiedemann… - Proceedings of the …, 2021 - National Acad Sciences
Genomic imprinting occurs before fertilization, impacts every cell of the developing child, and
may be sensitive to environmental perturbations. The noncoding RNA, nc886 (also called …
may be sensitive to environmental perturbations. The noncoding RNA, nc886 (also called …
Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT: AP-1 signaling
DNA methyltransferase inhibitor (DNMTi) efficacy in solid tumors is limited. Colon cancer
cells exposed to DNMTi accumulate lysine-27 trimethylation on histone H3 (H3K27me3). We …
cells exposed to DNMTi accumulate lysine-27 trimethylation on histone H3 (H3K27me3). We …
[PDF][PDF] Acute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome
RL Tiedemann, EL Putiri, JH Lee, RA Hlady… - Cell reports, 2014 - cell.com
Global patterns of DNA methylation, mediated by the DNA methyltransferases (DNMTs), are
disrupted in all cancers by mechanisms that remain largely unknown, hampering their …
disrupted in all cancers by mechanisms that remain largely unknown, hampering their …