To elucidate molecular mechanisms underlying activity-dependent synaptic remodeling in
the developing mammalian visual system, we screened for genes whose expression in the …

Scientific evidence continues to demonstrate the linkage of vascular contributions to
cognitive impairment and dementia such as Alzheimer's disease. In December, 2013, the …

Intrinsic antioxidant defenses are important for neuronal longevity. We found that in rat
neurons, synaptic activity, acting via NMDA receptor (NMDAR) signaling, boosted antioxidant …

White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance
imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small …

Vascular contributions to cognitive impairment and dementia (VCID) are characterized by
the aging neurovascular unit being confronted with and failing to cope with biological insults …

The World Health Organization reports that 47.5 million people are affected by dementia
worldwide. With aging populations and 7.7 million new cases each year, the burden of illness …

Goal 1 of the National Plan to Address Alzheimer’s Disease is to prevent and effectively treat
Alzheimer disease and Alzheimer disease–related dementias by 2025. To help inform the …

Bosetti et al NINDS Workshop Recommendations 2633 academia, industry, the Food and
Drug Administration, and other public and private funding agencies. In the context of this …

The National Alzheimer's Project Act, signed into law in 2011, mandates a National Plan to
Address Alzheimer's Disease that is updated annually. In the Plan, the term Alzheimer …

Objective: For 3,670 stroke patients from the United Kingdom, United States, Australia,
Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity …