Injury models have suggested that the lung contains anatomically and functionally distinct
epithelial stem cell populations. We have isolated such a regional pulmonary stem cell …

Background: The p53 tumor suppressor gene is mutated in a large percentage of human
malignancies, including tumors of the colon, breast, lung and brain. Individuals who inherit one …

The chemokine stromal cell-derived factor 1, SDF-1, is an important regulator of leukocyte
and hematopoietic precursor migration and pre-B cell proliferation. The receptor for SDF-1, …

The p63 gene, a homologue of the tumour-suppressor p53 ( 1 – 5 ), is highly expressed in
the basal or progenitor layers of many epithelial tissues 1 . Here we report that mice …

The retinoblastoma gene is mutated in several types of human cancer and is the best
characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one …

NF-κB, which consists of two polypeptides, p50 (M r 50K) and p65/RelA (M r 65K), is thought
to be a key regulator of genes involved in responses to infection, inflammation and stress 1 . …

Adenocarcinoma of the lung is the most common form of lung cancer, but the cell of origin
and the stages of progression of this tumor type are not well understood. We have developed …

miR-17∼92, miR-106b∼25, and miR-106a∼363 belong to a family of highly conserved
miRNA clusters. Amplification and overexpression of miR-17∼92 is observed in human cancers…

The c-abl proto-oncogene, which encodes a cytoplasmic protein-tyrosine klnase, isexpressed
throughout murine gestatlon and ubiquitously in adult mouse tissues. However, its levels …

The p53 tumor suppressor gene is commonly altered in human tumors, predominantly through
missense mutations that result in accumulation of mutant p53 protein. These mutations …