User profiles for Roger Foo
 | Roger FooProfessor, National University of Singapore Verified email at nus.edu.sg Cited by 8315 |
A meta-analysis on the global prevalence, risk factors and screening of coronary heart disease in nonalcoholic fatty liver disease
…, EY Tan, EXX Tan, YY Dan, PH Loh, R Foo… - Clinical …, 2022 - Elsevier
Background & Aims Cardiovascular disease remains the leading cause of death in patients
with nonalcoholic fatty liver disease (NAFLD). Studies examining the association of coronary …
with nonalcoholic fatty liver disease (NAFLD). Studies examining the association of coronary …
[HTML][HTML] Death begets failure in the heart
Recently, low — but abnormal — rates of cardiomyocyte apoptosis have been observed in
failing human hearts. Genetic and pharmacological studies suggest that this cell death is …
failing human hearts. Genetic and pharmacological studies suggest that this cell death is …
[HTML][HTML] Engineered circular RNA sponges act as miRNA inhibitors to attenuate pressure overload-induced cardiac hypertrophy
Circular RNAs (circRNAs) sequester microRNAs (miRNAs) and repress their endogenous
activity. We hypothesized that artificial circRNA sponges (circmiRs) can be constructed to …
activity. We hypothesized that artificial circRNA sponges (circmiRs) can be constructed to …
[HTML][HTML] MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes
The World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) as a
public health emergency of international concern as more than 15 million cases were …
public health emergency of international concern as more than 15 million cases were …
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A landscape of circular RNA expression in the human heart
…, TDA Luu, PYQ Li, AM Richards, RSY Foo - Cardiovascular …, 2017 - academic.oup.com
Aims Circular RNA (circRNA) is a newly validated class of single-stranded RNA, ubiquitously
expressed in mammalian tissues and possessing key functions including acting as …
expressed in mammalian tissues and possessing key functions including acting as …
[HTML][HTML] Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing …
…, J Tan, S Liu, P Zhang, Z Tiang, Z Chen, RSY Foo… - Cell death & …, 2020 - nature.com
Human pluripotent stem cells (hPSCs)-derived cardiovascular progenitor cells (CVPCs) are
a promising source for myocardial repair, while the mechanisms remain largely unknown. …
a promising source for myocardial repair, while the mechanisms remain largely unknown. …
[HTML][HTML] What we know about cardiomyocyte dedifferentiation
Cardiomyocytes (CMs) lost during cardiac injury and heart failure (HF) cannot be replaced
due to their limited proliferative capacity. Regenerating the failing heart by promoting CM cell-…
due to their limited proliferative capacity. Regenerating the failing heart by promoting CM cell-…
[HTML][HTML] Role of vascular smooth muscle cell plasticity and interactions in vessel wall inflammation
…, T Kofidis, CC Woo, XY Lin, R Foo… - Frontiers in …, 2020 - frontiersin.org
The pathobiology of atherosclerotic disease requires further elucidation to discover new
approaches to address its high morbidity and mortality. To date, over 17 million cardiovascular-…
approaches to address its high morbidity and mortality. To date, over 17 million cardiovascular-…
[HTML][HTML] Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure
Epigenetic mechanisms such as microRNA and histone modification are crucially responsible
for dysregulated gene expression in heart failure. In contrast, the role of DNA methylation, …
for dysregulated gene expression in heart failure. In contrast, the role of DNA methylation, …
[HTML][HTML] Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo
…, PYQ Li, TDA Luu, M Ackers-Johnson, RS Foo - Nature …, 2017 - nature.com
Cardiac regeneration may revolutionize treatment for heart failure but endogenous
progenitor-derived cardiomyocytes in the adult mammalian heart are few and pre-existing adult …
progenitor-derived cardiomyocytes in the adult mammalian heart are few and pre-existing adult …