The kidney is faced with unique challenges for oxygen regulation, both because its function
requires that perfusion greatly exceeds that required to meet metabolic demand and …

… Roger G Evans … Roger G Evans … (Artists impression of the renal cortical circulation
reproduced with permission from O’Connor and Evans.61) (b) In the medulla, the counter-current …

AKI is a common complication of sepsis and is significantly associated with mortality. Sepsis
accounts for more than 50% of the cases of AKI , with a mortality rate of up to 40%. The …

Norepinephrine is the principal vasopressor used to restore blood pressure in sepsis, but its
effects on intrarenal oxygenation are unknown. To clarify this, we examined renal cortical, …

Background Information and communication technology (ICT) offers considerable potential
for supporting older adults in managing their health, including chronic diseases. However, …

There is much evidence that the medullary circulation plays a key role in regulating renal
salt and water handling and, accordingly, the long-term level of arterial pressure. It has also …

Renal perfusion provides the driving pressure for glomerular filtration and delivers the oxygen
and nutrients to fuel solute reabsorption. Renal ischaemia is a major mechanism in acute …

Tissue hypoxia has been proposed as an important factor in the pathophysiology of both
chronic kidney disease (CKD) and acute kidney injury (AKI), initiating and propagating a vicious …

Sexual dimorphism in arterial pressure regulation has been observed in humans and animal
models. The mechanisms underlying this gender difference are not fully known. Previous …

Objectives: To determine whether there is a decrease in renal cortical or medullary perfusion
and oxygenation in a conscious large animal model of hyperdynamic septic shock with …