[HTML][HTML] Apoptosis in myocytes in end-stage heart failure
…, TG DiSalvo, FD Kolodgie, RJ Hajjar… - … England Journal of …, 1996 - Mass Medical Soc
Background Heart failure can result from a variety of causes, including ischemic, hypertensive,
toxic, and inflammatory heart disease. However, the cellular mechanisms responsible for …
toxic, and inflammatory heart disease. However, the cellular mechanisms responsible for …
Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy
Characterized by ventricular dilatation, systolic dysfunction, and progressive heart failure,
dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy in patients. DCM is …
dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy in patients. DCM is …
Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a
…, GW Dec, JK Gwathmey, A Rosenzweig, RJ Hajjar - Circulation, 1999 - Am Heart Assoc
Background—Failing human myocardium is characterized by abnormal relaxation, a deficient
sarcoplasmic reticulum (SR) Ca 2+ uptake, and a negative frequency response, which …
sarcoplasmic reticulum (SR) Ca 2+ uptake, and a negative frequency response, which …
Empagliflozin ameliorates adverse left ventricular remodeling in nondiabetic heart failure by enhancing myocardial energetics
…, E Flores, A Garcia-Ropero, J Sanz, RJ Hajjar… - Journal of the American …, 2019 - jacc.org
Background : Empagliflozin cardiac benefits in the EMPA-REG OUTCOME (Empagliflozin
Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients) trial cannot be …
Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients) trial cannot be …
Functional consequences of caspase activation in cardiac myocytes
…, J Narula, RJ Solaro, RJ Hajjar - Proceedings of the …, 2002 - National Acad Sciences
Cardiomyocyte apoptosis is present in many cardiac disease states, including heart failure
and ischemic heart disease. Apoptosis is associated with the activation of caspases that …
and ischemic heart disease. Apoptosis is associated with the activation of caspases that …
Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo
…, L Li, M Picard, TL Force, TF Franke, RJ Hajjar… - Circulation, 2001 - Am Heart Assoc
Background The serine-threonine kinase Akt is activated by several ligand-receptor systems
previously shown to be cardioprotective. Akt activation reduces cardiomyocyte apoptosis in …
previously shown to be cardioprotective. Akt activation reduces cardiomyocyte apoptosis in …
Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID) a phase 2 trial of intracoronary gene therapy of sarcoplasmic …
…, A Yaroshinsky, KM Zsebo, H Dittrich, RJ Hajjar - Circulation, 2011 - Am Heart Assoc
Background— Adeno-associated virus type 1/sarcoplasmic reticulum Ca 2+ -ATPase was
assessed in a randomized, double-blind, placebo-controlled, phase 2 study in patients with …
assessed in a randomized, double-blind, placebo-controlled, phase 2 study in patients with …
Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair
B Kühn, F Del Monte, RJ Hajjar, YS Chang… - Nature medicine, 2007 - nature.com
Adult mammalian hearts respond to injury with scar formation and not with cardiomyocyte
proliferation, the cellular basis of regeneration. Although cardiogenic progenitor cells may …
proliferation, the cellular basis of regeneration. Although cardiogenic progenitor cells may …
Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice
…, F Han, M Scherrer-Crosbie, TH Aretz, R Hajjar… - Circulation, 2001 - Am Heart Assoc
Background To test whether deficiency in endothelial nitric oxide synthase (eNOS) affects
atherosclerosis development, we compared lesion formation in apolipoprotein E (apoE)/eNOS-…
atherosclerosis development, we compared lesion formation in apolipoprotein E (apoE)/eNOS-…
Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure
…, A Rosenzweig, RJ Hajjar - Proceedings of the …, 2000 - National Acad Sciences
In human and experimental models of heart failure, sarcoplasmic reticulum Ca 2+ ATPase (SERCA2a)
activity is decreased, resulting in abnormal calcium handling. The disturbances in …
activity is decreased, resulting in abnormal calcium handling. The disturbances in …