Human pluripotent stem cells (hPSCs)-derived cardiovascular progenitor cells (CVPCs) are
a promising source for myocardial repair, while the mechanisms remain largely unknown. …

The neonatal mammalian heart is capable of regeneration for a brief window of time after
birth. However, this regenerative capacity is lost within the first week of life, which coincides …

Aims We and others have previously described the expression landscape of circular RNA (circRNA)
in mouse and human hearts. However, the functional relevance of many of these …

Hepatocellular carcinoma (HCC) has one of the poorest survival rates among cancers. Using
multi-regional sampling of nine resected HCC with different aetiologies, here we construct …

Mutations in the LaminA gene are a common cause of monogenic dilated cardiomyopathy.
Here we show that mice with a cardiomyocyte-specific Lmna deletion develop cardiac failure …

The combination of next-generation sequencing, advanced bioinformatics analysis, and
molecular research has now established circular RNAs (circRNAs) as a heterogeneous group of …

The mammalian heart contains heterogeneous cell types contributing to pathological
changes in cardiac disease. In this Comment, we explore how single-cell transcriptomic …

Background The consumption of wolfberry (Lycium barbarum), a rich source of carotenoids
and bioactive polysaccharides, may serve as a potential dietary strategy for cardiovascular …

Intra-tumor heterogeneity (ITH) is a key challenge in cancer treatment, but previous studies
have focused mainly on the genomic alterations without exploring phenotypic (transcriptomic …

Background: The human genome folds in 3 dimensions to form thousands of chromatin
loops inside the nucleus, encasing genes and cis-regulatory elements for accurate gene …