Many nanosized particulate systems are being developed as intravascular carriers to increase
the levels of therapeutic agents delivered to targets, with the fewest side effects 1 , 2 . The …

RNA interference (RNAi) is a powerful approach for silencing genes associated with a variety
of pathologic conditions; however, in vivo RNAi delivery has remained a major challenge …

Indocyanine green (ICG), a FDA approved near infrared (NIR) fluorescent agent, is used in
the clinic for a variety of applications including lymphangiography, intra-operative lymph …

Endothelial targeting is an approach evolving for drug delivery to the vasculature of pathological
lesions. Nano-porous silicon-based multi-functional particles are of particular interest, …

Injectable and implantable porosified silicon (pSi) carriers and devices for prolonged and
controlled delivery of biotherapeutics offer great promise for treatment of various chronic …

Fluorescence imaging in the second near-infrared window (NIR-II) holds promise for real-time
deep tissue imaging. In this work, we investigated the NIR-II fluorescence properties of a …

Recent developments in multi-functional nanoparticles offer a great potential for targeted
delivery of therapeutic compounds and imaging contrast agents to specific cell types, in turn, …

Background— The accumulation of macrophages in inflamed atherosclerotic plaques has
long been recognized. In an attempt to develop an imaging agent for detection of vulnerable …

Extracellular amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles constitute the
major neuropathological hallmarks of Alzheimer’s disease (AD). It is now apparent that …

Introduction Non-invasive 3D imaging that enables clear visualization of placental margins
is of interest in the accurate diagnosis of placental pathologies. This study investigated if …