Combinatorial interactions among transcription factors are critical to directing tissue-specific
gene expression. To build a global atlas of these combinations, we have screened for …

Macropinocytosis represents a distinct pathway of endocytosis in mammalian cells. This
actin‐driven endocytic process is not directly co‐ordinated by the presence of cargo but can be …

SOX5P (Table 2). Other fragments corresponding to al., 2000) has been exploited in many
laboratories to parts of SOX2,-17,-20, and-30 can be found in the identify approximately 30 …

Each organelle of the secretory pathway is required to selectively allow transit of newly
synthesized secretory and plasma membrane proteins and also to maintain a unique set of …

The synthesis of the visible pigment melanin by the melanocyte cell is the basis of the human
pigmentary system, those genes directing the formation, transport and distribution of the …

The mammalian genome encodes 49 proteins that possess a PX (phox-homology) domain,
responsible for membrane attachment to organelles of the secretory and endocytic system …

Retromer is a peripheral membrane protein complex that coordinates multiple vesicular
trafficking events within the endolysosomal system. Here, we demonstrate that retromer is …

The Trypanosomatidae comprise a large group of parasitic protozoa, some of which cause
important diseases in humans. These include Trypanosoma brucei (the causative agent of …

The retromer is a trimeric cargo‐recognition protein complex composed of Vps26, Vps29 and
Vps35 associated with protein trafficking within endosomes. Recently, a pathogenic point …

The polypeptide backbones and side chains of proteins are constantly moving due to
thermal motion and the kinetic energy of the atoms. The B‐factors of protein crystal structures …