Detection of SARS-CoV-2 with a CRISPR-Based Test A new method for the detection of
SARS-CoV-2 combines simplified extraction of RNA with isothermal amplification and CRISPR (…

Programmable genome integration of large, diverse DNA cargo without DNA repair of
exposed DNA double-strand breaks remains an unsolved challenge in genome editing. We …

Programmable approaches to sense and respond to the presence of specific RNAs in
biological systems have broad applications in research, diagnostics, and therapeutics. Here we …

Key points Imbalances in the activity of the D1‐expressing direct pathway and D2‐expressing
indirect pathway striatal projection neurons (SPNs) are thought to contribute to many basal …

The diversity of cell types and states can be scalably measured and defined by expressed
RNA transcripts. However, approaches to programmably sense and respond to the presence …

A dysfunctional striatum is thought to contribute to neurodevelopmental disorders such as
ADHD, Tourette’s syndrome and OCD. Insight into these disorders is reliant on an …

Heterogeneous populations of neural progenitors in the embryonic lateral ganglionic eminence
(LGE) generate all GABAergic spiny projection neurons (SPNs) found in the striatum. …

CRISPR–Cas interference is mediated by Cas effector nucleases that are either components
of multisubunit complexes—in class 1 CRISPR–Cas systems—or domains of a single …

Synaptic circuits in the brain are precisely organized, but the processes that govern this
precision are poorly understood. Here, we explore how distinct embryonic neural progenitor …

Synaptic circuits in the brain are precisely organized, but the processes that govern this
precision are poorly understood. Here we explored how distinct embryonic neural progenitor …