Background: Technological advances raise the possibility of systematic population-based
genetic testing for cancer-predisposing mutations, but it is uncertain whether benefits …

Background: Population-based testing for BRCA1/2 mutations detects the high proportion of
carriers not identified by cancer family history (FH)–based testing. We compared the cost-…

Objective To assess the efficacy and safety of subcutaneous ketamine for geriatric treatment-resistant
depression. Secondary aims were to examine if repeated treatments were safe …

Objectives: Repetitive transcranial magnetic stimulation (rTMS) is increasingly being utilised
as a treatment option for depression, and with this comes a need for a practical review of …

Milroy disease ( MD ) is an autosomal dominantly inherited primary lymphedema. In 1998,
the gene locus for MD was mapped to 5q35.3 and variants in the VEGFR3 (FLT4) gene, …

J. Neurochem. (2010) 112, 112–122. Abstract There is substantial evidence that abnormal
concentrations of oxidised tryptophan metabolites, produced via the kynurenine pathway, …

Background BRCA carrier identification offers opportunities for early diagnoses, targeted
treatment and cancer prevention. We evaluate BRCA- carrier detection rates in general and …

Background Newer approaches to genetic counselling are required for population-based
testing. We compare traditional face-to-face genetic counselling with a DVD-assisted approach …

Angelman syndrome (AS) and Prader–Willi syndrome (PWS) are caused by genetic and
epigenetic mutations of the imprinted gene cluster on chromosome 15q13. Although the …

Background Our aim was to develop a new protocol for MGMT immunohistochemistry with
good agreement between observers and good correlation with molecular genetic tests of …