Background Meningococcal conjugate vaccines protect individuals directly, but can also
confer herd protection by interrupting carriage transmission. We assessed the effects of …

Objectives Outpatient parenteral antibiotic therapy (OPAT) is an effective treatment strategy
for a wide variety of infections as long as clinical risk is minimized by conforming to practice …

Neutrophils are implicated in the pathogenesis of atherosclerosis but are seldom detected
in atherosclerotic plaques. We investigated whether neutrophil-derived microvesicles may …

Objectives Infections with extended-spectrum-β-lactamase-producing organisms are an
increasing public health concern. We reviewed the use of an outpatient parenteral antibiotic …

Objective Bacterial infection contributes to diverse noninfectious diseases and worsens outcome
after stroke. Streptococcus pneumoniae, the most common infection in patients at risk of …

Background University students have high rates of pharyngeal carriage of Neisseria meningitidis.
Interruption of carriage acquisition is an important mechanism of vaccines for inducing …

Cardiovascular disease has emerged as the leading cause of mortality worldwide. Acute
coronary syndromes occur as a result of thrombotic complications at the site of atherosclerotic …

Allergic bronchopulmonary aspergillosis and invasive fungal diseases represent distinct
infectious entities that cause significant morbidity and mortality. Currently, administered inhaled …

Objectives Chronic pulmonary aspergillosis (CPA) is associated with significant mortality,
and suboptimal antifungal treatment response. We describe predictive factors for treatment …

Aspergillus causes a broad range of diseases for which there are limited antifungal drug
treatment options—a problem that is exacerbated by the emerging threat of antifungal drug …