A gene–environment-induced epigenetic program initiates tumorigenesis
…, C Burdziak, JLV Maag, JP Morris IV, R Chandwani… - Nature, 2021 - nature.com
Tissue damage increases the risk of cancer through poorly understood mechanisms 1 . In
mouse models of pancreatic cancer, pancreatitis associated with tissue injury collaborates …
mouse models of pancreatic cancer, pancreatitis associated with tissue injury collaborates …
Suppression of inflammation by a synthetic histone mimic
…, S Beinke, S Dewell, C Chung, R Chandwani… - Nature, 2010 - nature.com
Interaction of pathogens with cells of the immune system results in activation of inflammatory
gene expression. This response, although vital for immune defence, is frequently …
gene expression. This response, although vital for immune defence, is frequently …
α-Ketoglutarate links p53 to cell fate during tumour suppression
JP Morris IV, JJ Yashinskie, R Koche, R Chandwani… - Nature, 2019 - nature.com
The tumour suppressor TP53 is mutated in the majority of human cancers, and in over 70%
of pancreatic ductal adenocarcinoma (PDAC) 1 , 2 . Wild-type p53 accumulates in response …
of pancreatic ductal adenocarcinoma (PDAC) 1 , 2 . Wild-type p53 accumulates in response …
Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis
…, KL Jeffrey, R Chandwani… - Proceedings of the …, 2010 - National Acad Sciences
Canonical animal microRNAs (miRNAs) are generated by sequential cleavage of precursor
substrates by the Drosha and Dicer RNase III enzymes. Several variant pathways exploit …
substrates by the Drosha and Dicer RNase III enzymes. Several variant pathways exploit …
Genetic determinants of outcome in intrahepatic cholangiocarcinoma
…, BG Koerkamp, M Doukas, R Chandwani… - …, 2021 - Wiley Online Library
Background and Aim Genetic alterations in intrahepatic cholangiocarcinoma (iCCA) are
increasingly well characterized, but their impact on outcome and prognosis remains unknown. …
increasingly well characterized, but their impact on outcome and prognosis remains unknown. …
The NF-κB transcriptional footprint is essential for SARS-CoV-2 replication
…, RE Schwartz, BR Rosenberg, R Chandwani… - Journal of …, 2021 - Am Soc Microbiol
SARS-CoV-2, the etiological agent of COVID-19, is characterized by a delay in type I
interferon (IFN-I)-mediated antiviral defenses alongside robust cytokine production. Here, we …
interferon (IFN-I)-mediated antiviral defenses alongside robust cytokine production. Here, we …
Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response
…, V Parravicini, RK Prinjha, R Chandwani… - Journal of Experimental …, 2012 - rupress.org
Effective antiviral immunity depends on the ability of infected cells or cells triggered with
virus-derived nucleic acids to produce type I interferon (IFN), which activates transcription of …
virus-derived nucleic acids to produce type I interferon (IFN), which activates transcription of …
[PDF][PDF] The SS18-SSX oncoprotein hijacks KDM2B-PRC1. 1 to drive synovial sarcoma
Synovial sarcoma is an aggressive cancer invariably associated with a chromosomal
translocation involving genes encoding the SWI-SNF complex component SS18 and an SSX (…
translocation involving genes encoding the SWI-SNF complex component SS18 and an SSX (…
[HTML][HTML] Uncertain beginnings: acinar and ductal cell plasticity in the development of pancreatic cancer
A Grimont, SD Leach, R Chandwani - Cellular and molecular …, 2022 - Elsevier
The pancreas consists of several specialized cell types that display a remarkable ability to
alter cellular identity in injury, regeneration, and repair. The abundant cellular plasticity within …
alter cellular identity in injury, regeneration, and repair. The abundant cellular plasticity within …
Cystic neoplasms of the pancreas
R Chandwani, PJ Allen - Annual review of medicine, 2016 - annualreviews.org
Cystic neoplasms of the pancreas are being identified at an increasing frequency largely due
to the increased use of abdominal cross-sectional imaging. These neoplasms represent a …
to the increased use of abdominal cross-sectional imaging. These neoplasms represent a …