Onset of cardiovascular complications as a consequence of atherosclerosis exhibits a
circadian incidence with a peak in the morning hours. Although development of atherosclerosis …

Myeloid-related proteins (MRPs) 8 and 14 are cytosolic proteins secreted from myeloid cells
as proinflammatory mediators. Currently, the functional role of circulating extracellular MRP8…

The recruitment of neutrophils to sites of inflammation, their battle against invading microorganisms
through phagocytosis and the release of antimicrobial agents is a highly coordinated …

Tissue resident mast cells (MCs) rapidly initiate neutrophil infiltration upon inflammatory
insult, yet the molecular mechanism is still unknown. Here, we demonstrated that MC-derived …

Neutrophils are key players during host defense and sterile inflammation. Neutrophil dysfunction
is a characteristic feature of the acquired immunodeficiency during kidney disease. We …

S100A8/S100A9 is a proinflammatory mediator released by myeloid cells during many acute
and chronic inflammatory disorders. However, the precise mechanism of its release from …

Neutrophils need to penetrate the perivascular basement membrane for successful extravasation
into inflamed tissue, but this process is incompletely understood. Recent findings have …

During inflammation, neutrophils are one of the first responding cells of innate immunity,
contributing to a fast clearance of infection and return to homeostasis. However, excessive …

Aims Neutrophil trafficking within the vasculature strongly relies on intracellular calcium
signalling. Sustained Ca 2+ influx into the cell requires a compensatory efflux of potassium to …

Objective— Platelet function has been intensively studied in the adult organism. However,
little is known about the function and hemostatic capacity of platelets in the developing fetus …