User profiles for Roland Le Borgne

Roland Le Borgne

CNRS Research Director
Verified email at univ-rennes1.fr
Cited by 5413

Drosophila S2 cells secrete wingless on exosome‐like vesicles but the wingless gradient forms independently of exosomes

…, H Green, E Bonneil, G Raposo, P Thibault, RL Borgne… - Traffic, 2013 - Wiley Online Library
Wingless acts as a morphogen in Drosophila wing discs, where it specifies cell fates and
controls growth several cell diameters away from its site of expression. Thus, despite being …

Ezrin has properties to self-associate at the plasma membrane

C Andréoli, M Martin, RL Borgne… - Journal of cell …, 1994 - journals.biologists.com
Ezrin, a member of a family of proteins involved in the interaction of the microfilament cytoskeleton
with the plasma membrane, plays a role in membrane translocation in gastric parietal …

Mannose 6-phosphate receptors regulate the formation of clathrin-coated vesicles in the TGN

RL Borgne, B Hoflack - The Journal of cell biology, 1997 - rupress.org
The transport of the two mannose 6-phosphate receptors (MPRs) from the secretory
pathway to the endocytic pathway is mediated by carrier vesicles coated with the AP-1 Golgi-specific …

Small and stable peptidic PEGylated quantum dots to target polyhistidine-tagged proteins with controlled stoichiometry

…, P Neveu, F Vignaux, RL Borgne… - Journal of the …, 2009 - ACS Publications
The use of the semiconductor quantum dots (QD) as biolabels for both ensemble and single-molecule
tracking requires the development of simple and versatile methods to target …

Genetic identification of intracellular trafficking regulators involved in Notch-dependent binary cell fate acquisition following asymmetric cell division

…, G Kriegel-Taki, A Dussert, RL Borgne - Journal of cell …, 2012 - journals.biologists.com
Notch signalling is involved in numerous cellular processes during development and throughout
adult life. Although ligands and receptors are largely expressed in the whole organism, …

Assembly, dynamics and remodeling of epithelial cell junctions throughout development

M Mira-Osuna, RL Borgne - Development, 2024 - journals.biologists.com
Cell junctions play key roles in epithelial integrity. During development, when epithelia
undergo extensive morphogenesis, these junctions must be remodeled in order to maintain …

Cell-intrinsic and -extrinsic roles of the ESCRT-III subunit Shrub in abscission of Drosophila sensory organ precursors

…, E Daniel, M Daudé, J Mathieu, RL Borgne - …, 2023 - journals.biologists.com
Although the molecular mechanisms governing abscission of isolated cells have largely
been elucidated, those underlying the abscission of epithelial progenitors surrounded by …

The roles of receptor and ligand endocytosis in regulating Notch signaling

R Le Borgne, A Bardin, F Schweisguth - 2005 - journals.biologists.com
Cell-cell signaling is a central process in the formation of multicellular organisms. Notch (N)
is the receptor of a conserved signaling pathway that regulates numerous developmental …

Regulation of Notch signalling by endocytosis and endosomal sorting

R Le Borgne - Current opinion in cell biology, 2006 - Elsevier
Cell–cell signalling is an essential process in the formation of multicellular organisms. Notch
is the receptor of an evolutionarily conserved signalling pathway regulating numerous …

ESCRT-III-dependent adhesive and mechanical changes are triggered by a mechanism detecting alteration of Septate Junction integrity in Drosophila epithelial cells

…, MK Jaglarz, E Durel, R Le Borgne - Elife, 2024 - elifesciences.org
Barrier functions of proliferative epithelia are constantly challenged by mechanical and chemical
constraints. How epithelia respond to and cope with disturbances of barrier functions to …