Metabolic reprogramming has been proposed to be a hallmark of cancer, yet a systematic
characterization of the metabolic pathways active in transformed cells is currently lacking. …

Metabolic remodeling is now widely regarded as a hallmark of cancer, but it is not clear
whether individual metabolic strategies are frequently exploited by many tumours. Here we …

Most cells have the inherent capacity to shift their reliance on glycolysis relative to oxidative
metabolism, and studies in model systems have shown that targeting such shifts may be …

Objectives: Despite a growing interest in evidence‐based practice (EBP), the implementation
into clinical practice of knowledge derived from research has proved to be a cumbersome …

We propose algorithms for learning Markov boundaries from data without having to learn a
Bayesian network first. We study their correctness, scalability and data efficiency. The last two …

The STIM1–ORAI1 pathway of store-operated Ca 2+ entry is an essential component of cellular
Ca 2+ signalling 1 . STIM1 senses depletion of intracellular Ca 2+ stores in response to …

Heme biosynthesis consists of a series of eight enzymatic reactions that originate in
mitochondria and continue in the cytosol before returning to mitochondria. Although these core …

We analyze two different feature selection problems: finding a minimal feature set optimal
for classification (MINIMAL-OPTIMAL) vs. finding all features relevant to the target variable (…

The human oxidative phosphorylation (OxPhos) system consists of approximately 90
proteins encoded by nuclear and mitochondrial genomes and serves as the primary cellular …

Environmental exposures filtered through the genetic make-up of each individual alter the
transcriptional repertoire in organs central to metabolic homeostasis, thereby affecting arterial …