Abstract Characterization of previously described intraflagellar transport (IFT) mouse mutants
has led to the proposition that normal primary cilia are required for mammalian cells to …

In this study we investigate the roles of the organizer factors chordin and noggin, which are
dedicated antagonists of the bone morphogenetic proteins(BMPs), in formation of the …

The neural crest is a multipotent, migratory cell population arising from the border of the
neural and surface ectoderm. In mouse, the initial migratory neural crest cells occur at the five-…

Genetic mapping of mutations in model systems has facilitated the identification of genes
contributing to fundamental biological processes including human diseases. However, this …

Here we investigate the roles of the Bone Morphogenetic Protein (BMP) antagonists Chordin
and Noggin in development of the mandible, which is derived from the first branchial arch (…

Pediatric hydrocephalus is characterized by an abnormal accumulation of cerebrospinal
fluid (CSF) and is one of the most common congenital brain abnormalities. However, little is …

Here we characterize the consequences of elevated bone morphogenetic protein (BMP)
signaling on neural tube morphogenesis by analyzing mice lacking the BMP antagonist, Noggin…

Sphingomyelinases generate ceramide from sphingomyelin as a second messenger in
intracellular signaling pathways involved in cell proliferation, differentiation, or apoptosis. …

The three nicotinamide mononucleotide adenylyltransferase (NMNAT) family members
synthesize the electron carrier nicotinamide adenine dinucleotide (NAD + ) and are essential for …

Heterozygous pathogenic variants in POLR1A, which encodes the largest subunit of RNA
Polymerase I, were previously identified as the cause of acrofacial dysostosis, Cincinnati-type. …