Background Significant paravalvular leakage after transcatheter aortic valve implantation (TAVI)
correlates with increased morbidity and mortality, but adverse consequences of trivial …

Methods: Several prosthetic valves were tested in a pulse duplicator under simulated
cardiac conditions. A unique prototype subsystem (LeonardoVSI) was used to measure the …

Background Exploration for causes of prosthetic valve thrombogenicity has frequently
focused on forward or post-closure flow detail. In prior laboratory studies, we uncovered high …

Valvular heart disease remains a large public health problem for all societies; it attracts the
attention of public health organizations, researchers and governments. Valve substitution is …

From the early 1960s to the late 1990s, prosthetic heart valve designs were improved through
intense scientific and clinical feedback. Mechanical heart valves, however, still require …

With great interest, we read the recent paper by Rashid et al1. Their meta-analysis of six
observational studies revealed that leaflet thrombosis is associated with a significantly …

As there is currently no suitable valved pulmonary conduit for small children, porcine conduits
treated by the L-Hydro process were implanted into 9 newborn lambs to investigate growth …

Structured Abstract Objectives We hypothesize that prosthetic valve thrombogenic potential
may be inferred by valve regional flow velocity. This metric was used to compare two clinical …

Objective To demonstrate a clear link between predicted blood shear forces during valve
closure and thrombogenicity that explains the thrombogenic difference between tissue and …

Methods Valves were tested in aortic and mitral sites under pulsatile circulation in a pulse
duplicator. An optical approach measures dynamic valve area. Pulsatile fluid dynamics were …