Hybridization of eggs and sperm from closely related species can give rise to genetic diversity,
or can lead to embryo inviability owing to incompatibility. Although central to evolution, …

γ-Tubulin complexes are essential for microtubule (MT) nucleation. The γ-tubulin small
complex (γ-TuSC) consists of two molecules of γ-tubulin and one molecule each of Spc97 and …

Background Genome duplication has played a pivotal role in the evolution of many eukaryotic
lineages, including the vertebrates. A relatively recent vertebrate genome duplication is …

Microtubules are tubes of about 25 nm in diameter that are critically involved in a variety of
cellular functions, including motility, compartmentalization, and division. They are considered …

Among different species or cell types, or during early embryonic cell divisions that occur in
the absence of cell growth, the size of subcellular structures, including the nucleus, …

Multinucleated cells are important in many organisms, but the mechanisms governing the
movements of nuclei sharing a common cytoplasm are not understood. In the hyphae of the …

Nuclear migration during yeast karyogamy, termed nuclear congression, is required to initiate
nuclear fusion. Congression involves a specific regulation of the microtubule minus end-…

Cytoskeleton-mediated transport processes are central to the subcellular organization of
cells. The nucleus constitutes the largest organelle of a cell, and studying how it is positioned …

The spindle is crucial for cell division by allowing the faithful segregation of replicated
chromosomes to daughter cells. Proper segregation is ensured only if microtubules (MTs) and …

Egg extracts of the African clawed frog Xenopus laevis have provided a cell‐free system
instrumental in elucidating events of the cell cycle, including mechanisms of spindle assembly. …