Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms
on the transcriptome. To investigate the genetics of gene expression, we performed cis…

Long-range interactions between regulatory elements and gene promoters play key roles in
transcriptional regulation. The vast majority of interactions are uncharted, constituting a …

The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …

While many disease-associated variants have been identified through genome-wide association
studies, their downstream molecular consequences remain unclear. To identify these …

Background : Inflammation drives atherosclerotic plaque rupture. Although inflammation can
be measured using fluorine-18-labeled fluorodeoxyglucose positron emission tomography (…

12. Assisted Human Reproduction Act, SC 2004. http://laws-lois. justice. gc. ca/PDF/A-13.4.
pdf (2018) 13. CNN. Rael defends claims of cloned baby. http://www. cnn. com/2003/…

Blood cells contain functionally important intracellular structures, such as granules, critical to
immunity and thrombosis. Quantitative variation in these structures has not been subjected …

Linking non-coding genetic variants associated with the risk of diseases or disease-relevant
traits to target genes is a crucial step to realize GWAS potential in the introduction of …

The interindividual variation in the functional response of platelets to activation by agonists
is heritable. Genome-wide association studies (GWASs) of quantitative measures of platelet …

New minimal invasive diagnostic methods for early detection of lung cancer are urgently
needed. It is known that the immune system responds to tumors with production of tumor-…