Methods for in vitro DNA cleavage and molecular cloning remain unable to precisely cleave
DNA directly adjacent to bases of interest. Restriction enzymes (REs) must bind specific …

CRISPR nucleases generate a broad spectrum of mutations that includes undesired editing
outcomes. Here, we develop optimized C-to-T base editing systems for the generation of …

Spinal muscular atrophy (SMA) is a devastating neuromuscular disease caused by mutations
in the SMN1 gene. Despite the development of various therapies, outcomes can remain …

Spinal muscular atrophy (SMA) is caused by mutations in SMN1. SMN2 is a paralogous gene
with a C•G-to-T•A transition in exon 7, which causes this exon to be skipped in most SMN2 …

CRISPR nucleases generate a broad spectrum of mutations that includes undesired editing
outcomes which attenuate phenotypes and complicate experimental analysis and …

We investigate the previously proposed cyclic regime of the Kosterlitz–Thouless renormalization
group (RG) flows. The period of one cycle is computed in terms of the RG invariant. …

We show that a simple extension of the standard BCS Hamiltonian leads to an infinite number
of BCS eigenstates with different energy gaps and self-similar properties, described by a …

While restriction enzymes (REs) remain the gold-standard for manipulating DNA in vitro,
they have notable drawbacks including a dependence on short binding motifs that constrain …

… Similar dolls appear in other tomb contexts from the middle … What did this particular form of
grave good mean in its Roman … before assuming that dolls were placed in Roman tombs for …

Heterocyclic amines found in well-done meat require host-mediated metabolic activation
before initiating DNA mutations and tumors in target organs. Polymorphic N-acetyltransferase-2(…