Mammalian genomes are spatially organized into compartments, topologically associating
domains (TADs), and loops to facilitate gene regulation and other chromosomal functions. …

Mammalian imprinted genes often cluster with long noncoding (lnc) RNAs. Three lncRNAs
that induce parental-specific silencing show hallmarks indicating that their transcription is …

Mammalian genomes are spatially organized by CCCTC-binding factor (CTCF) and cohesin
into chromatin loops 1 , 2 and topologically associated domains 3 , 4 , 5 , 6 , which have …

Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into
numerous loops. “Loop extrusion” can be impeded by chromatin-bound factors, such as CTCF, …

It is currently assumed that 3D chromosomal organization plays a central role in transcriptional
control. However, depletion of cohesin and CTCF affects the steady-state levels of only a …

Background Whenever different data sets arrive at conflicting phylogenetic hypotheses, only
testable causal explanations of sources of errors in at least one of the data sets allow us to …

Eukaryotic genomes are compacted into loops and topologically associating domains (TADs)
1 , 2 – 3 , which contribute to transcription, recombination and genomic stability 4 , 5 . …

Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin
complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is …

Ribosomal RNA (rRNA) genes are probably the most frequently used data source in
phylogenetic reconstruction. Individual columns of rRNA alignments are not independent as a …

10.7554/eLife.46269.001 The organisation of mammalian genomes into loops and topologically
associating domains (TADs) contributes to chromatin structure, gene expression and …