Recently, organoid technology has been used to generate a large repository of breast
cancer organoids. Here we present an extensive evaluation of the ability of organoid culture …

NRG1 rearrangements encode chimeric ligands that activate the ERBB receptor tyrosine
kinase family. Here we show that targeting HER2 and HER3 simultaneously with the bispecific …

The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables on …

PD-1 blockade is highly effective in classical Hodgkin lymphomas (cHLs), which exhibit
frequent copy-number gains of CD274 (PD-L1) and PDC1LG2 (PD-L2) on chromosome 9p24.1. …

In classical Hodgkin lymphoma (cHL), the host antitumor immune response is ineffective.
Hodgkin Reed-Sternberg (HRS) cells have multifaceted mechanisms to evade the immune …

Metastatic breast cancer is the major cause of cancer-related death among women in the
Western world. Invasive carcinoma cells are able to counteract apoptotic signals in the …

To decipher the molecular mechanisms of biological function, it is critical to map the molecular
composition of individual cells or even more importantly tissue samples in the context of …

The epithelial adherens junction is an E-cadherin-based complex that controls tissue integrity
and is stabilized at the plasma membrane by p120-catenin (p120, also known as CTNND1)…

YAP is a transcriptional coactivator that controls organ expansion and differentiation and is
inhibited by the Hippo pathway in cells in interphase. Here, we demonstrated that, during …

Metastatic breast cancer remains the chief cause of cancer-related death among women in
the Western world. Although loss of cell–cell adhesion is key to breast cancer progression, …