User profiles for Ron Diskin
 | Ron DiskinDepartment of Chemical and Structural Biology Weizmann Institute of Science Verified email at weizmann.ac.il Cited by 5986 |
Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding
JF Scheid, H Mouquet, B Ueberheide, R Diskin, F Klein… - Science, 2011 - science.org
Passive transfer of broadly neutralizing HIV antibodies can prevent infection, which suggests
that vaccines that elicit such antibodies would be protective. Thus far, however, few broadly …
that vaccines that elicit such antibodies would be protective. Thus far, however, few broadly …
[HTML][HTML] Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization
Broadly neutralizing antibodies (bNAbs) to HIV-1 can prevent infection and are therefore of
great importance for HIV-1 vaccine design. Notably, bNAbs are highly somatically mutated …
great importance for HIV-1 vaccine design. Notably, bNAbs are highly somatically mutated …
[HTML][HTML] Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs
Vaccine candidates for HIV-1 so far have not been able to elicit broadly neutralizing antibodies
(bNAbs) although they express the epitopes recognized by bNAbs to the HIV envelope …
(bNAbs) although they express the epitopes recognized by bNAbs to the HIV envelope …
Restricting HIV-1 pathways for escape using rationally designed anti–HIV-1 antibodies
R Diskin, F Klein, JA Horwitz… - Journal of Experimental …, 2013 - rupress.org
Recently identified broadly neutralizing antibodies (bNAbs) that potently neutralize most HIV-1
strains are key to potential antibody-based therapeutic approaches to combat HIV/AIDS in …
strains are key to potential antibody-based therapeutic approaches to combat HIV/AIDS in …
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
…, S Bournazos, H Mouquet, LA Spatz, R Diskin… - Nature, 2012 - nature.com
Human antibodies to human immunodeficiency virus-1 (HIV-1) can neutralize a broad range
of viral isolates in vitro and protect non-human primates against infection 1 , 2 . Previous …
of viral isolates in vitro and protect non-human primates against infection 1 , 2 . Previous …
Increasing the potency and breadth of an HIV antibody by using structure-based rational design
R Diskin, JF Scheid, PM Marcovecchio, AP West Jr… - Science, 2011 - science.org
Antibodies against the CD4 binding site (CD4bs) on the HIV-1 spike protein gp120 can show
exceptional potency and breadth. We determined structures of NIH45-46, a more potent …
exceptional potency and breadth. We determined structures of NIH45-46, a more potent …
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques
…, D Montefiori, B Moldt, P Poignard, R Diskin… - Journal of Experimental …, 2014 - rupress.org
It is widely appreciated that effective human vaccines directed against viral pathogens elicit
neutralizing antibodies (NAbs). The passive transfer of anti–HIV-1 NAbs conferring sterilizing …
neutralizing antibodies (NAbs). The passive transfer of anti–HIV-1 NAbs conferring sterilizing …
[PDF][PDF] Longitudinal isolation of potent near-germline SARS-CoV-2-neutralizing antibodies from COVID-19 patients
…, T Wolf, MJGT Vehreschild, C Wendtner, R Diskin… - Cell, 2020 - cell.com
The SARS-CoV-2 pandemic has unprecedented implications for public health, social life,
and the world economy. Because approved drugs and vaccines are limited or not available, …
and the world economy. Because approved drugs and vaccines are limited or not available, …
Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120
AP West Jr, R Diskin… - Proceedings of the …, 2012 - National Acad Sciences
A large number of anti–HIV-1 antibodies targeting the CD4-binding site (CD4bs) on the
envelope glycoprotein gp120 have recently been reported. These antibodies, typified by VRC01, …
envelope glycoprotein gp120 have recently been reported. These antibodies, typified by VRC01, …
[PDF][PDF] Assembly mechanism of mucin and von Willebrand factor polymers
The respiratory and intestinal tracts are exposed to physical and biological hazards
accompanying the intake of air and food. Likewise, the vasculature is threatened by inflammation …
accompanying the intake of air and food. Likewise, the vasculature is threatened by inflammation …