3 Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus:
implications for virus origins and receptor binding. Lancet 2020; published online Jan …

Secreted IgM and complement are important mediators in the optimal initiation of primary T-dependent
humoral immune responses. Secreted IgM serves as a natural adjuvant by …

Although TLR9 was originally thought to specifically recognize microbial DNA, it is now
evident that mammalian DNA can be an effective TLR9 ligand. However, the DNA sequence …

Marburg and Ebola viruses cause a severe hemorrhagic disease in humans with high fatality
rates. Early target cells of filoviruses are monocytes, macrophages, and dendritic cells. The …

On Feb 19, 2020, we, a group of physicians, veterinarians, epi demiologists, virologists,
biologists, ecologists, and public health experts from around the world, joined together to …

Mosquito-borne arboviruses are a major source of human disease. One strategy to reduce
arbovirus disease is to reduce the mosquito's ability to transmit virus. Mosquito infection with …

Secreted IgM is predominantly found as pentameric molecules, but IgM can also be secreted
as hexamers by B cell lines. Murine hexamers activate the complement cascade more …

The inducible B cell lymphoma, CH12, and its in vitro adapted subclone, CH12‐LBK, produce
immunoglobulins of identical sequence, specificity and isotype, with equivalent affinities …

Two functional polymeric forms of IgM can be produced by antibody-secreting B cells.
Hexameric IgM lacks detectable J (joining) chain and activates complement 17-fold better than …

… and Ronald Corley discuss how the ‘quality control' mechanisms that regulate IgM assembly
and secretion play important roles in the developmental progression of B cells and in B-cell …