We introduce and validate a new precision oncology framework for the systematic prioritization
of drugs targeting mechanistic tumor dependencies in individual patients. Compounds …

Phosphoinositide 3-kinase (PI3K) and the proteasome pathway are both involved in activating
the mechanistic target of rapamycin (mTOR). Because mTOR signaling is required for …

These findings provide evidence that inhibitors of NF-κB signaling synergize with BET inhibition
in in vitro and in vivo models, suggesting a clinical utility of these targeted therapies in …

Pathological activation of the thyroid-stimulating hormone receptor (TSHR) is caused by
thyroid-stimulating antibodies in patients with Graves’ disease (GD) or by somatic and rare …

Our ability to discover effective drug combinations is limited, in part by insufficient
understanding of how the transcriptional response of two monotherapies results in that of their …

Most antiviral agents are designed to target virus-specific proteins and mechanisms rather
than the host cell proteins that are critically dysregulated following virus-mediated …

Alvarez et al. reply—Quantitative, objective metrics to assess the fidelity of cancer models—such
as cell lines, organoids or patient-derived xenografts—remain elusive, and histological …

SARS-CoV-2 hijacks the host cell transcriptional machinery to induce a phenotypic state
amenable to its replication. Here we show that analysis of Master Regulator proteins …

Quantitative metrics to objectively assess the fidelity of cancer models, such as cell lines,
organoids, or patient-derived xenografts (PDXs), remain elusive, with histological criteria or the …

Precise characterization and targeting of host cell transcriptional machinery hijacked by
SARS-CoV-2 remains challenging. To identify therapeutically targetable mechanisms that are …