[HTML][HTML] Natural history, outcome, and treatment efficacy in children and adults with glutaryl-CoA dehydrogenase deficiency
Glutaryl-CoA dehydrogenase (GCDH) deficiency is a rare inborn disorder of l-lysine, l-hydroxylysine,
and l-tryptophan metabolism complicated by striatal damage during acute …
and l-tryptophan metabolism complicated by striatal damage during acute …
Deconvolution gas chromatography/mass spectrometry of urinary organic acids–potential for pattern recognition and automated identification of metabolic disorders
…, WG Mallard, S Down, RA Chalmers - … in mass spectrometry, 1999 - Wiley Online Library
The National Institute of Standards and Technology (NIST) Automated Mass Spectral
Deconvolution and Identification System (AMDIS) is applied to a selection of data files obtained …
Deconvolution and Identification System (AMDIS) is applied to a selection of data files obtained …
[HTML][HTML] Functional genomics of Neisseria meningitidis pathogenesis
YH Sun, S Bakshi, R Chalmers, CM Tang - Nature medicine, 2000 - nature.com
The pathogenic bacterium Neisseria meningitidis is an important cause of septicemia and
meningitis, especially in childhood 1. The establishment and maintenance of bacteremic …
meningitis, especially in childhood 1. The establishment and maintenance of bacteremic …
[HTML][HTML] Accuracy and efficiency define Bxb1 integrase as the best of fifteen candidate serine recombinases for the integration of DNA into the human genome
Background Phage-encoded serine integrases, such as φC31 integrase, are widely used
for genome engineering. Fifteen such integrases have been described but their utility for …
for genome engineering. Fifteen such integrases have been described but their utility for …
Temperature triggers immune evasion by Neisseria meningitidis
…, A Tracy, Q Zhang, B Gollan, H Ewles, R Chalmers… - Nature, 2013 - nature.com
Neisseria meningitidis has several strategies to evade complement-mediated killing, and
these contribute to its ability to cause septicaemic disease and meningitis. However, the …
these contribute to its ability to cause septicaemic disease and meningitis. However, the …
Delivering the goods: viral and non-viral gene therapy systems and the inherent limits on cargo DNA and internal sequences
H Atkinson, R Chalmers - Genetica, 2010 - Springer
Viruses have long been considered to be the most promising tools for human gene therapy.
However, the initial enthusiasm for the use of viruses has been tarnished in the light of …
However, the initial enthusiasm for the use of viruses has been tarnished in the light of …
[HTML][HTML] IHF modulation of Tn10 transposition: sensory transduction of supercoiling status via a proposed protein/DNA molecular spring
R Chalmers, A Guhathakurta, H Benjamin, N Kleckner - Cell, 1998 - cell.com
Architectural protein IHF modulates Tn10 transposition in vitro. IHF stimulates transposon
excision. Also, separately, IHF forces transposon end/target DNA interactions into a …
excision. Also, separately, IHF forces transposon end/target DNA interactions into a …
The human SETMAR protein preserves most of the activities of the ancestral Hsmar1 transposase
…, N Buisine, Y Bigot, R Chalmers - … and cellular biology, 2007 - Am Soc Microbiol
Transposons have contributed protein coding sequences to a unexpectedly large number of
human genes. Except for the V (D) J recombinase and telomerase, all remain of unknown …
human genes. Except for the V (D) J recombinase and telomerase, all remain of unknown …
Mariner and the ITm superfamily of transposons
M Tellier, CC Bouuaert, R Chalmers - Mobile DNA III, 2015 - Wiley Online Library
The mariner elements belong to the ITm superfamily of cut‐and‐paste DNA‐transposons.
The acronym is derived from the IS630, Tc1, and mariner elements, which represent three …
The acronym is derived from the IS630, Tc1, and mariner elements, which represent three …
Identification of a gene (lpt‐3) required for the addition of phosphoethanolamine to the lipopolysaccharide inner core of Neisseria meningitidis and its role in …
…, PA Coull, JC Wright, R Chalmers… - Molecular …, 2002 - Wiley Online Library
We have identified a gene, lpt‐3, that is required for the addition of phosphoethanolamine to
the 3‐position (PEtn‐3) on the β‐chain heptose (HepII) of the inner core lipopolysaccharide (…
the 3‐position (PEtn‐3) on the β‐chain heptose (HepII) of the inner core lipopolysaccharide (…