MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation
RN Germain - Cell, 1994 - Elsevier
The immune system has developed a variety of mecharmisms for sensing the presence of
invading microorganisms, which must be accomplished in the face of special topological …
invading microorganisms, which must be accomplished in the face of special topological …
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
…, TH Nasti, AH Sharpe, GJ Freeman, RN Germain… - Nature, 2016 - nature.com
Chronic viral infections are characterized by a state of CD8 + T-cell dysfunction that is associated
with expression of the programmed cell death 1 (PD-1) inhibitory receptor 1 , 2 , 3 , 4 . …
with expression of the programmed cell death 1 (PD-1) inhibitory receptor 1 , 2 , 3 , 4 . …
House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
…, M Chieppa, F Perros, MA Willart, RN Germain… - Nature medicine, 2009 - nature.com
Barrier epithelial cells and airway dendritic cells (DCs) make up the first line of defense
against inhaled substances such as house dust mite (HDM) allergen and endotoxin (…
against inhaled substances such as house dust mite (HDM) allergen and endotoxin (…
T-cell development and the CD4–CD8 lineage decision
RN Germain - Nature reviews immunology, 2002 - nature.com
Cell-fate decisions are controlled typically by conserved receptors that interact with co-evolved
ligands. Therefore, the lineage-specific differentiation of immature CD4 + CD8 + T cells …
ligands. Therefore, the lineage-specific differentiation of immature CD4 + CD8 + T cells …
The biochemistry and cell biology of antigen processing and presentation
RN Germain, DH Margulies - Annual review of immunology, 1993 - annualreviews.org
T lymphocytes with rxf3 receptors recognize antigen in association with the polymorphic
products of the class I and class II loci of the major histocompatibility complex (MHC). This …
products of the class I and class II loci of the major histocompatibility complex (MHC). This …
[HTML][HTML] Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes
…, JP Laugier, F Brau, N Glaichenhaus, RN Germain - Immunity, 2006 - cell.com
After entry into lymph nodes (LNs), B cells migrate to follicles, whereas T cells remain in the
paracortex, with each lymphocyte type showing apparently random migration within these …
paracortex, with each lymphocyte type showing apparently random migration within these …
In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies
…, S Kamhawi, P Lawyer, MP Fay, RN Germain… - Science, 2008 - science.org
Infection with the obligate intracellular protozoan Leishmania is thought to be initiated by
direct parasitization of macrophages, but the early events following transmission to the skin by …
direct parasitization of macrophages, but the early events following transmission to the skin by …
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
…, R Goldbach-Mansky, DB Sacks, RN Germain… - Nature, 2012 - nature.com
Mutations in the gene encoding NLRP3 cause a spectrum of autoinflammatory diseases
known as cryopyrin-associated periodic syndromes (CAPS) 1 . NLRP3 is a key component of …
known as cryopyrin-associated periodic syndromes (CAPS) 1 . NLRP3 is a key component of …
In vivo microbial stimulation induces rapid CD40 ligand–independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas
…, D Jankovic, H Charest, RN Germain… - The Journal of …, 1997 - rupress.org
The early induction of interleukin (IL)-12 is a critical event in determining the development of
both innate resistance and adaptive immunity to many intracellular pathogens. Previous in …
both innate resistance and adaptive immunity to many intracellular pathogens. Previous in …
Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell–dendritic cell interaction
…, G Altan-Bonnet, S Stoll, C Scheinecker, RN Germain - Nature, 2006 - nature.com
CD8 + T cells have a crucial role in resistance to pathogens and can kill malignant cells;
however, some critical functions of these lymphocytes depend on helper activity provided by a …
however, some critical functions of these lymphocytes depend on helper activity provided by a …