The active site of the Haloalkane Dehydrogenase (HaloTag) enzyme can be covalently
attached to a chloroalkane ligand providing a mechanically strong tether, resistant to large …

Biomolecular interactions frequently occur in orientation-specific manner. For example, prior
nuclear magnetic resonance spectroscopy experiments in our lab have suggested the …

Cell-surface proteins are central for the interaction of cells with their surroundings and are
also associated with numerous diseases. These molecules are exposed to mechanical forces, …

Single-molecule force spectroscopy has opened up new approaches to the study of protein
dynamics. For example, an extended protein folding after an abrupt quench in the pulling …

The elastic restoring force of tissues must be able to operate over the very wide range of
loading rates experienced by living organisms. It is surprising that even the fastest events …

The opportunistic pathogen, Pseudomonas aeruginosa, a flagellated bacterium, is one of
the top model organisms for biofilm studies. To elucidate the location of bacterial flagella …

We use Langevin dynamics to investigate the role played by the recently discovered force-induced
entropic energy barrier on the two-state hopping phenomena that has been observed …

Chitosan hydrogels have widespread industrial applications due to their versatility and
antimicrobial potential. However, their applicability can be limited by poor mechanical properties …

Single-molecule force spectroscopy utilizes polyproteins, which are composed of tandem
modular domains, to study their mechanical and structural properties. Under the application of …

Ultrafast folding proteins have limited cooperativity and thus are excellent models to resolve,
via single-molecule experiments, the fleeting molecular events that proteins undergo during …