The structural basis for the divalent cation–dependent binding of heterodimeric αβ integrins
to their ligands, which contain the prototypical Arg-Gly-Asp sequence, is unknown. …

Integrins are αβ heterodimeric receptors that mediate divalent cation-dependent cell-cell and
cell-matrix adhesion through tightly regulated interactions with ligands. We have solved the …

The structure of the I domain of integrin αLβ2 bound to the Ig superfamily ligand ICAM-1 reveals
the open ligand binding conformation and the first example of an integrin-IgSF interface. …

A novel human coronavirus, Middle East respiratory syndrome coronavirus (MERS-CoV),
has caused outbreaks of a SARS-like illness with high case fatality rate. The reports of its …

USP7/HAUSP is a key regulator of p53 and Mdm2 and is targeted by the Epstein-Barr nuclear
antigen 1 (EBNA1) protein of Epstein-Barr virus (EBV). We have determined the crystal …

Nonstructural protein 14 (nsp14) of coronaviruses (CoV) is important for viral replication and
transcription. The N-terminal exoribonuclease (ExoN) domain plays a proofreading role for …

The crystal structure of a complex involving the D10 T cell receptor (TCR), 16-residue foreign
peptide antigen, and the IA k self major histocompatibility complex (MHC) class II molecule …

STING is an essential signaling molecule for DNA and cyclic di-GMP (c-di-GMP)-mediated
type I interferon (IFN) production via TANK-binding kinase 1 (TBK1) and interferon regulatory …

The recent emergence of highly pathogenic avian influenza A virus strains with subtype H5N1
pose a global threat to human health 1 . Elucidation of the underlying mechanisms of viral …

The oncoprotein large tumour antigen (LTag) is encoded by the DNA tumour virus simian
virus 40. LTag transforms cells and induces tumours in animals by altering the functions of …