The human genome is segmented into topologically associating domains (TADs), but the role
of this conserved organization during transient changes in gene expression is not known. …

Key nuclear processes in eukaryotes, including DNA replication, repair, and gene regulation,
require extensive chromatin remodeling catalyzed by energy-consuming enzymes. It …

Eukaryotic gene regulation implies that transcription factors gain access to genomic information
via poorly understood processes involving activation and targeting of kinases, histone-…

With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of
nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in ADP-…

The post-translational modification of key residues at the C-terminal domain of RNA polymerase
II (RNAP2-CTD) coordinates transcription, splicing, and RNA processing by modulating …

In breast cancer cells, some topologically associating domains (TADs) behave as hormonal
gene regulation units, within which gene transcription is coordinately regulated in response …

Misregulation of the processes controlling eukaryotic gene expression can result in disease.
Gene expression is influenced by the surrounding chromatin; hence the nuclear …

Despite global research efforts, breast cancer remains the leading cause of cancer death in
women worldwide. The majority of these deaths are due to metastasis occurring years after …

The growth of cancer cells as oncospheres in three-dimensional (3D) culture provides a robust
cell model for understanding cancer progression, as well as for early drug discovery and …

Cyclin-dependent kinase inhibitor 1A (Cip1/Waf1/CDKN1A/p21) is a well-established protein,
primarily recognised for its pivotal role in the cell cycle, where it induces cell cycle arrest by …