[HTML][HTML] Comparative cellular analysis of motor cortex in human, marmoset and mouse
…, A Bartlett, D Bertagnolli, T Casper, RG Castanon… - Nature, 2021 - nature.com
The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …
[HTML][HTML] DNA methylation atlas of the mouse brain at single-cell resolution
Mammalian brain cells show remarkable diversity in gene expression, anatomy and function,
yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly …
yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly …
Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells
10.7554/eLife.36187.001 Vascular endothelial cell (EC) function depends on appropriate
organ-specific molecular and cellular specializations. To explore genomic mechanisms that …
organ-specific molecular and cellular specializations. To explore genomic mechanisms that …
Single-cell DNA methylation and 3D genome architecture in the human brain
Delineating the gene-regulatory programs underlying complex cell types is fundamental for
understanding brain function in health and disease. Here, we comprehensively examined …
understanding brain function in health and disease. Here, we comprehensively examined …
[HTML][HTML] Single-cell DNA methylome and 3D multi-omic atlas of the adult mouse brain
…, J Altshul, JR Nery, H Chen, RG Castanon… - Nature, 2023 - nature.com
Cytosine DNA methylation is essential in brain development and is implicated in various
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …
Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse
…, A Bartlett, D Bertagnolli, T Casper, RG Castanon… - BioRxiv, 2020 - biorxiv.org
The primary motor cortex (M1) is essential for voluntary fine motor control and is functionally
conserved across mammals. Using high-throughput transcriptomic and epigenomic profiling …
conserved across mammals. Using high-throughput transcriptomic and epigenomic profiling …
[HTML][HTML] Spatiotemporal DNA methylome dynamics of the developing mouse fetus
Cytosine DNA methylation is essential for mammalian development but understanding of its
spatiotemporal distribution in the developing embryo remains limited 1 , 2 . Here, as part of …
spatiotemporal distribution in the developing embryo remains limited 1 , 2 . Here, as part of …
[HTML][HTML] Conserved and divergent gene regulatory programs of the mammalian neocortex
Divergence of cis-regulatory elements drives species-specific traits 1 , but how this manifests
in the evolution of the neocortex at the molecular and cellular level remains unclear. Here …
in the evolution of the neocortex at the molecular and cellular level remains unclear. Here …
Improved regulatory element prediction based on tissue-specific local epigenomic signatures
Accurate enhancer identification is critical for understanding the spatiotemporal
transcriptional regulation during development as well as the functional impact of disease-related …
transcriptional regulation during development as well as the functional impact of disease-related …
[HTML][HTML] Epigenomic diversity of cortical projection neurons in the mouse brain
…, L Boggeman, C Fitzpatrick, JR Nery, RG Castanon… - Nature, 2021 - nature.com
Neuronal cell types are classically defined by their molecular properties, anatomy and functions.
Although recent advances in single-cell genomics have led to high-resolution molecular …
Although recent advances in single-cell genomics have led to high-resolution molecular …