OBJECTIVE Despite their origins in different germ layers, pancreatic islet cells share many
common developmental features with neurons, especially serotonin-producing neurons in the …

In the developing pancreas, the basic helix–loop–helix (bHLH) protein Neurogenin3 (Ngn3)
specifies which precursor cells ultimately will become endocrine cells and initiates the islet …

During fetal development, paired/homeodomain transcription factor Pax4 controls the
formation of the insulin-producing β cells and the somatostatin-producing δ cells in the islets of …

Insulin receptor substrate 2 (IRS2) is a widely expressed protein that regulates crucial
biological processes including glucose metabolism, protein synthesis, and cell survival. IRS2 is …

Proopiomelanocortin (POMC) neurons are critical sensors of nutrient availability implicated
in energy balance and glucose metabolism control. However, the precise mechanisms …

Glycogen-targeting subunits of protein phosphatase-1 facilitate interaction of the phosphatase
with enzymes of glycogen metabolism. We have shown that overexpression of one …

Direct lineage reprogramming of one somatic cell into another without transitioning through
a progenitor stage has emerged as a strategy to generate clinically relevant cell types. One …

The pancreatic β-cell transcriptome is highly sensitive to external signals such as glucose
oscillations and stress cues. MicroRNAs (miRNAs) have emerged as key factors in gene …

Expanding the mass of pancreatic insulin-producing beta cells through re-activation of beta
cell replication has been proposed as a therapy to prevent or delay the appearance of …

The transcription factor Neurogenin3 functions as a master regulator of endocrine pancreas
formation, and its deficiency leads to the development of diabetes in humans and mice. In …