The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that
orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone marrow. …

A single protein, HMGB 1, directs the triggering of inflammation, innate and adaptive immune
responses, and tissue healing after damage. HMGB 1 is the best characterized damage‐…

High Mobility Group Box 1 protein was discovered as a nuclear protein, but it has a ⿿second
life⿿ outside the cell where it acts as a damage-associated molecular pattern. HMGB1 is …

Simple Summary Chemokines are small soluble proteins that control and regulate cell trafficking
within and between tissues by binding to their receptors. Among them, CXCL12 and its …

Background The hypothesis that most cancers are of monoclonal origin is often accepted as
a fact in the scientific community. This dogma arose decades ago, primarily from the study of …

Extracellular HMGB 1 triggers inflammation following infection or injury and supports
tumorigenesis in inflammation‐related malignancies. HMGB 1 has several redox states: reduced …

Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and
treat. Here we describe the molecular, cellular and morphological characterization of a …

Epidermal growth factor receptor (EGFR) gene mutational analysis is critical for guiding the
treatment of lung adenocarcinoma. In everyday clinical practice, EGFR testing is frequently …

Chemokine heterodimers activate or dampen their cognate receptors during inflammation.
The CXCL12 chemokine forms with the fully reduced (fr) alarmin HMGB1 a physiologically …

Boosting antitumor immunity has emerged as a powerful strategy in cancer treatment. While
releasing T‐cell brakes has received most attention, tumor recognition by T cells is a pre‐…