User profiles for Rosela Golloshi
Rosela GolloshiPostdoctoral Research Fellow, Johns Hopkins School of Medicine Verified email at jhmi.edu Cited by 215 |
Iteratively improving Hi-C experiments one step at a time
The 3D organization of eukaryotic chromosomes affects key processes such as gene
expression, DNA replication, cell division, and response to DNA damage. The genome-wide …
expression, DNA replication, cell division, and response to DNA damage. The genome-wide …
[HTML][HTML] Radiation-induced DNA damage and repair effects on 3D genome organization
The three-dimensional structure of chromosomes plays an important role in gene expression
regulation and also influences the repair of radiation-induced DNA damage. Genomic …
regulation and also influences the repair of radiation-induced DNA damage. Genomic …
Chromosome compartmentalization alterations in prostate cancer cell lines model disease progression
Prostate cancer aggressiveness and metastatic potential are influenced by gene expression
and genomic aberrations, features that can be influenced by the 3D structure of …
and genomic aberrations, features that can be influenced by the 3D structure of …
[HTML][HTML] Loops, topologically associating domains, compartments, and territories are elastic and robust to dramatic nuclear volume swelling
Layers of genome organization are becoming increasingly better characterized, but less is
known about how these structures respond to perturbation or shape changes. Low-salt …
known about how these structures respond to perturbation or shape changes. Low-salt …
Constricted migration is associated with stable 3D genome structure differences in cancer cells
R Golloshi, C Playter, TF Freeman, P Das, TI Raines… - EMBO …, 2022 - embopress.org
To spread from a localized tumor, metastatic cancer cells must squeeze through constrictions
that cause major nuclear deformations. Since chromosome structure affects nucleus …
that cause major nuclear deformations. Since chromosome structure affects nucleus …
Investigation of spatial organization of chromosome territories in chromosome exchange aberrations after ionizing radiation exposure
Higher-order organization of the human genome is well established with chromosomes
occupying distinct domains or territories in the interphase nucleus. Spatial organization of …
occupying distinct domains or territories in the interphase nucleus. Spatial organization of …
Genome organization during the cell cycle: unity in division
R Golloshi, JT Sanders… - … Reviews: Systems Biology …, 2017 - Wiley Online Library
During the cell cycle, the genome must undergo dramatic changes in structure, from a
decondensed, yet highly organized interphase structure to a condensed, generic mitotic …
decondensed, yet highly organized interphase structure to a condensed, generic mitotic …
Using contact statistics to characterize structure transformation of biopolymer ensembles
As a unique subset of functional polymers, many biopolymers have a set of well-defined
three-dimensional (3D) structural characteristics that can be described by spatial contacts …
three-dimensional (3D) structural characteristics that can be described by spatial contacts …
Constricted migration is associated with stable 3D genome structure differences in cancer cell
R Golloshi, C Playter, TF Freeman, P Das, TI Raines… - bioRxiv, 2019 - biorxiv.org
To spread from a localized tumor, metastatic cancer cells must squeeze through constrictions
that cause major nuclear deformations. Since chromosome structure affects nucleus …
that cause major nuclear deformations. Since chromosome structure affects nucleus …
[PDF][PDF] Constricted migration contributes to persistent 3D genome structure changes associated with an invasive phenotype in melanoma cells
R Golloshi, RS Martin, P Das, TI Raines, D Thurston… - BioRxiv, 2019 - academia.edu
To spread from a localized tumor, metastatic cancer cells must squeeze through constrictions
that cause major nuclear deformations. Since chromosome structure affects nucleus …
that cause major nuclear deformations. Since chromosome structure affects nucleus …