User profiles for Rosela Golloshi

Rosela Golloshi

Postdoctoral Research Fellow, Johns Hopkins School of Medicine
Verified email at jhmi.edu
Cited by 215

Iteratively improving Hi-C experiments one step at a time

R Golloshi, JT Sanders, RP McCord - Methods, 2018 - Elsevier
The 3D organization of eukaryotic chromosomes affects key processes such as gene
expression, DNA replication, cell division, and response to DNA damage. The genome-wide …

[HTML][HTML] Radiation-induced DNA damage and repair effects on 3D genome organization

JT Sanders, TF Freeman, Y Xu, R Golloshi… - Nature …, 2020 - nature.com
The three-dimensional structure of chromosomes plays an important role in gene expression
regulation and also influences the repair of radiation-induced DNA damage. Genomic …

Chromosome compartmentalization alterations in prostate cancer cell lines model disease progression

…, Y Xu, JM Roberts, JT Sanders, R Golloshi… - Journal of Cell …, 2021 - rupress.org
Prostate cancer aggressiveness and metastatic potential are influenced by gene expression
and genomic aberrations, features that can be influenced by the 3D structure of …

[HTML][HTML] Loops, topologically associating domains, compartments, and territories are elastic and robust to dramatic nuclear volume swelling

JT Sanders, R Golloshi, P Das, Y Xu, PH Terry… - Scientific Reports, 2022 - nature.com
Layers of genome organization are becoming increasingly better characterized, but less is
known about how these structures respond to perturbation or shape changes. Low-salt …

Constricted migration is associated with stable 3D genome structure differences in cancer cells

R Golloshi, C Playter, TF Freeman, P Das, TI Raines… - EMBO …, 2022 - embopress.org
To spread from a localized tumor, metastatic cancer cells must squeeze through constrictions
that cause major nuclear deformations. Since chromosome structure affects nucleus …

Investigation of spatial organization of chromosome territories in chromosome exchange aberrations after ionizing radiation exposure

AS Balajee, JT Sanders, R Golloshi, I Shuryak… - Health …, 2018 - journals.lww.com
Higher-order organization of the human genome is well established with chromosomes
occupying distinct domains or territories in the interphase nucleus. Spatial organization of …

Genome organization during the cell cycle: unity in division

R Golloshi, JT Sanders… - … Reviews: Systems Biology …, 2017 - Wiley Online Library
During the cell cycle, the genome must undergo dramatic changes in structure, from a
decondensed, yet highly organized interphase structure to a condensed, generic mitotic …

Using contact statistics to characterize structure transformation of biopolymer ensembles

P Das, R Golloshi, RP McCord, T Shen - Physical Review E, 2020 - APS
As a unique subset of functional polymers, many biopolymers have a set of well-defined
three-dimensional (3D) structural characteristics that can be described by spatial contacts …

Constricted migration is associated with stable 3D genome structure differences in cancer cell

R Golloshi, C Playter, TF Freeman, P Das, TI Raines… - bioRxiv, 2019 - biorxiv.org
To spread from a localized tumor, metastatic cancer cells must squeeze through constrictions
that cause major nuclear deformations. Since chromosome structure affects nucleus …

[PDF][PDF] Constricted migration contributes to persistent 3D genome structure changes associated with an invasive phenotype in melanoma cells

R Golloshi, RS Martin, P Das, TI Raines, D Thurston… - BioRxiv, 2019 - academia.edu
To spread from a localized tumor, metastatic cancer cells must squeeze through constrictions
that cause major nuclear deformations. Since chromosome structure affects nucleus …