Parkinson’s disease is a synucleinopathy that is characterized by motor dysfunction, death
of midbrain dopaminergic neurons and accumulation of α-synuclein (α-Syn) aggregates. …

We recently developed adeno-associated virus (AAV) capsids to facilitate efficient and
noninvasive gene transfer to the central and peripheral nervous systems. However, a detailed …

Recombinant adeno-associated viruses (AAVs) are commonly used gene delivery vehicles
for neuroscience research. They have two engineerable features: the capsid (outer protein …

Heart rate is under the precise control of the autonomic nervous system. However, the wiring
of peripheral neural circuits that regulate heart rate is poorly understood. Here, we develop …

In many sensory organs, specialized receptors are strategically arranged to enhance
detection sensitivity and acuity. It is unclear whether the olfactory system utilizes a similar …

Whether glutamate or itch-selective neurotransmitters are used to confer itch specificity is still
under debate. We focused on an itch-selective population of primary afferents expressing …

The adult olfactory epithelium (OE) regenerates sensory neurons and nonsensory
supporting cells from resident stem cells after injury. How supporting cells contribute to OE …

Taste cells in taste buds of the mammalian tongue and oral cavity can detect five basic
modalities: sweet, bitter, umami, salty, and sour. Each taste cell expresses distinct molecular …

We recently developed novel AAV capsids for efficient and noninvasive gene transfer across
the central and peripheral nervous systems. In this protocol, we describe how to produce …

We recently reported that olfactory sensory neurons in the dorsal zone of the mouse olfactory
epithelium exhibit drastic location-dependent differences in cilia length. Furthermore, …