Stimuli‐responsive biomaterials show great promise for modeling disease dynamics ex vivo
with spatiotemporal control over the cellular microenvironment. However, harvesting cells …

Dynamic fibroblast to myofibroblast state transitions underlie the heart's fibrotic response.
Because transcriptome maturation by muscleblind-like 1 (MBNL1) promotes differentiated cell …

Heart failure is the leading cause of death in the United States and rapidly becoming the
leading cause of death worldwide. While pharmacological treatments can reduce progression …

Patterned deposition and 3D fabrication techniques have enabled the use of hydrogels for a
number of applications including microfluidics, sensors, separations, and tissue …

Relating the macroscopic properties of protein-based materials to their underlying component
microstructure is an outstanding challenge. Here, we exploit computational design to …

Cells and their surrounding microenvironment exist in dynamic reciprocity, where
bidirectional feedback and feedforward crosstalk drives essential processes in development, …

Inherited mutations in contractile and structural genes, which decrease cardiomyocyte tension
generation, are principal drivers of dilated cardiomyopathy (DCM)– the leading cause of …

The colonic epithelium is continuously exposed to an array of biological and mechanical
stimuli as its luminal contents are guided over the epithelial surface through regulated smooth …

Hydrogel biomaterials have proven indispensable for three-dimensional (3D) cell culture but
have fallen short in replicating the innate physiochemical complexity of real tissue. Though …

Biomechanical contributions of the ECM underpin cell growth and proliferation, differentiation,
signal transduction, and other fate decisions. As such, biomaterials whose mechanics can …