Deregulated ribosomal RNA synthesis is associated with uncontrolled cancer cell proliferation.
RNA polymerase (Pol) I, the multiprotein complex that synthesizes rRNA, is activated …

Mammalian target of rapamycin (mTOR) is a key regulator of cell growth acting via two
independent targets, ribosomal protein S6 kinase 1 (S6K1) and 4EBP1. While each is known to …

Increased transcription of ribosomal RNA genes (rDNA) by RNA Polymerase I is a common
feature of human cancer, but whether it is required for the malignant phenotype remains …

For cancers to develop, sustain and spread, the appropriation of key homeostatic physiological
systems that influence cell growth, migration and death, as well as inflammation and the …

ATRX (alpha thalassemia/mental retardation syndrome X-linked) belongs to the SWI2/SNF2
family of chromatin remodeling proteins. Besides the ATPase/helicase domain at its C …

Current understanding of the mechanisms by which cell growth is regulated lags significantly
behind our knowledge of the complex processes controlling cell cycle progression. Recent …

The contribution of the nucleolus to cancer is well established with respect to its traditional
role in facilitating ribosome biogenesis and proliferative capacity. More contemporary studies …

Urotensin II (UII) is a somatostatin-like peptide recently identified as a potent vasoconstrictor.
In this study, we examined whether UII promotes cardiac remodeling through …

For over 100 years, pathologists have utilised an increase in size and number of nucleoli, the
subnuclear site of ribosome synthesis, as a marker of aggressive tumours. Despite this, the …

In mammals, the mechanisms regulating the number of active copies of the ∼200 ribosomal
RNA (rRNA) genes transcribed by RNA polymerase I are unclear. We demonstrate that …