In the Drosophila optic lobes, the medulla processes visual information coming from inner
photoreceptors R7 and R8 and from lamina neurons. It contains approximately 40,000 …

Stem cells, their niches, and their relationship to cancer are under intense investigation.
Because tumors and metastases acquire self-renewing capacity, mechanisms for their …

Animal appendages require a proximodistal (PD) axis, which forms orthogonally from the
two main body axes, anteroposterior and dorsoventral. In this review, we discuss recent …

We present a two-part system for conditional FLP-out of FRT-flanked sequences in
Caenorhabditis elegans to control gene activity in a spatially and/or temporally regulated manner. …

Hox proteins belong to a family of transcription factors with similar DNA binding specificities
that control animal differentiation along the antero-posterior body axis. Hox proteins are …

Specification of cell identity and the proper functioning of a mature cell depend on precise
regulation of gene expression. Both binary ON/OFF regulation of transcription, as well as more …

Ribosome biogenesis is a cell-essential process that influences cell growth, proliferation,
and differentiation. How ribosome biogenesis impacts development, however, is poorly …

The Yorkie/Yap transcriptional coactivator is a well-known regulator of cellular proliferation
in both invertebrates and mammals. As a coactivator, Yorkie (Yki) lacks a DNA binding …

We report molecular genetic studies of three genes involved in early germ-line proliferation
in Caenorhabditis elegans that lend unexpected insight into a germ-line/soma functional …

lim-7 is one of seven Caenorhabditis elegans LIM-homeodomain (LIM-HD)-encoding genes
and the sole Islet ortholog. LIM-HD transcription factors, including Islets, function in …