Effective SARS-CoV-2 vaccines are urgently needed. Although most vaccine strategies
have focused on systemic immunization, here we compared the protective efficacy of 2 …

Although histone modifications are associated with gene activities, studies of their causal
relationships have been difficult. For this purpose, we developed an inducible system …

The tremendous structural heterogeneity of N-glycosylation of glycoproteins poses a great
challenge for deciphering the biological functions of specific glycoforms and for developing …

Antibody–drug conjugates (ADCs) are an important class of therapeutic agents that harness
the highly specific antigen targeting property of antibodies to deliver toxic drugs for targeted …

Eliciting broadly neutralizing antibody (bNAb) responses against HIV-1 is a major goal for a
prophylactic HIV-1 vaccine. One approach is to design immunogens based on known …

The mammalian α1,6-fucosyltransferase (FUT8) catalyzes the core fucosylation of N-glycans
in the biosynthesis of glycoproteins. Previously, intensive in vitro studies with crude extract …

HIV-1 envelope glycoproteins gp120 and gp41 are presented on the virus surface as a trimer
of heterodimer and are the targets of broadly neutralizing antibodies (bNAbs). We describe …

The N‐glycan pattern of an IgG antibody, attached at a conserved site within the fragment
crystallizable (Fc) region, is a critical antibody quality attribute whose structural variability can …

Core fucosylation is the attachment of an α-1,6-fucose moiety to the innermost N-acetyl
glucosamine (GlcNAc) in N-glycans in mammalian systems. It plays a pivotal role in modulating …

Emergence of SARS-CoV-2 variants and waning of vaccine/infection-induced immunity
pose threats to curbing the COVID-19 pandemic. Effective, safe, and convenient booster …