THE slow-reacting substance of anaphylaxis was recognized as a discrete biologic entity 1 ,
2 three to four decades before it was chemically defined as three specific cysteinyl …

Identifying secreted mediators that drive the cognitive benefits of exercise holds great promise
for the treatment of cognitive decline in ageing or Alzheimer’s disease (AD). Here, we …

Human eosinophils were cultured in the presence of recombinant human IL-3 for up to 14 d
and their biochemical, functional, and density properties were assessed. After 3 d of culture …

BACKGROUND: Cigarette smoke–induced chronic obstructive pulmonary disease (COPD)
is a life-threatening inflammatory disorder of the lung. The development of effective therapies …

Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …

As described in the introduction to this Perspective series (1), signaling by arachidonic acid
represents a paradigm for the use of oxygen in the transmission of information. At the same …

CD177 is a glycosylphosphatidylinositol (GPI)-anchored protein expressed by a variable
proportion of human neutrophils that mediates surface expression of the antineutrophil …

Ly6G is a glycosylphosphatidylinositol (GPI)–anchored protein of unknown function that is
commonly targeted to induce experimental neutrophil depletion in mice. In the present study, …

Diversity of cytochrome P450 function is determined by the expression of multiple genes,
many of which have a high degree of identity. We report that the use of alternate exons, each …

Leukotrienes (LTs) are signaling molecules derived from arachidonic acid that initiate and
amplify innate and adaptive immunity. In turn, how their synthesis is organized on the nuclear …