Recent results indicate that many untranslating mRNAs in somatic eukaryotic cells assemble
into related mRNPs that accumulate in specific cytoplasmic foci referred to as P bodies. …

A fundamental aspect of the biogenesis and function of eukaryotic messenger RNA is the
quality control systems that recognize and degrade non-functional mRNAs. Eukaryotic mRNAs …

Stress granules are assemblies of untranslating messenger ribonucleoproteins (mRNPs) that
form from mRNAs stalled in translation initiation. Stress granules form through interactions …

The COVID-19 pandemic has created a public health crisis. Because SARS-CoV-2 can
spread from individuals with presymptomatic, symptomatic, and asymptomatic infections, the …

One role of messenger RNA (mRNA) degradation is to maintain the fidelity of gene expression
by degrading aberrant transcripts. Recent results show that mRNAs without translation …

Based on the above mechanisms of mRNA degradation, an integrated model of mRNA
turnover can be proposed (Figure 1). In this model, all polyadenylated mRNAs would be …

▪ Abstract Eukaryotic mRNAs are primarily degraded by removal of the 3′ poly(A) tail,
followed either by cleavage of the 5′ cap structure (decapping) and 5′->3′ exonucleolytic …

The control of translation and mRNA degradation is an important part of the regulation of
gene expression. It is now clear that small RNA molecules are common and effective …

A major pathway of eukaryotic messenger RNA (mRNA) turnover begins with deadenylation,
followed by decapping and 5′ to 3′ exonucleolytic decay. We provide evidence that …

Small RNAs, including small interfering RNAs (siRNAs) and microRNAs (miRNAs) can
silence target genes through several different effector mechanisms 1 . Whereas siRNA-directed …